Ferenc Ötvös

Csaba Vizler2
Zoltán Oláh2
Tamás Letoha2
2Csaba Vizler
2Zoltán Oláh
2Tamás Letoha
2László Pecze
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  • Zoltán Oláh, Katalin Jósvay, László Pecze, Tamás Letoha, Norbert Babai, Dénes Budai +3 others
  • 2007
Ca(2+)-loaded calmodulin normally inhibits multiple Ca(2+)-channels upon dangerous elevation of intracellular Ca(2+) and protects cells from Ca(2+)-cytotoxicity, so blocking of calmodulin should theoretically lead to uncontrolled elevation of intracellular Ca(2+). Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit(More)
Multidimensional QSAR methodologies can be used to predict the active conformation encoded in the conformational preferences of molecules in an active series by utilizing conformational sampling. In the 3+3D-QSAR approach, the conformational free energy loss is modeled with internal coordinate-based flexibility descriptors. While the pharmacophore point(More)
SUMMARY Researchers of various disciplines ranging from Life Sciences and Astronomy to Computational Chemistry, create and use scientific applications producing large amount of complex data relying heavily on compute-intensive modelling, simulation and analysis. Grid Computing provides an efficient way for parallelizing and gridifying computational and data(More)
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel involved in pain sensation and in a wide range of non-pain-related physiological and pathological conditions. The aim of the present study was to explore the effects of selected heavy metal cations on the function of TRPV1. The cations ranked in the following sequence of(More)
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