Ferdinand Kreuzer

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A shift of the oxygen dissociation curve to the right is often interpreted as an adaptation to hypoxia favorable for tissue oxygen supply. However, animals native to high altitude tend to show a rather high oxygen affinity. In order to elucidate this apparent discrepancy we investigated by numerical computer studies 1. the effect of a shift of the(More)
Normal subjects have a larger diffusing capacity normalized per liter alveolar volume (DL/VA) in the supine than in the sitting position. Body position changes total lung diffusing capacity (DL), DL/VA, membrane conductance (Dm), and effective pulmonary capillary blood volume (Qc) as a function of alveolar volume (VA). These functions were studied in 37(More)
During the past few years much progress has been made concerning the development of accurate chemical methods for the determination of adrenaline, noradrenaline, and hydroxy-methoxy mandelic acid in urine and blood plasma. The problem of establishing standard values for the healthy average adult human of both sexes has thus become more urgent. We determined(More)
Intravenous injection of gas (10–60 ml) causes acute pulmonary embolism, which disappears completely within 10–20 min. Intravenous infusion of gas (1–5 ml min−1) can be continued for a long time. During these infusions a steady state is reached in which pulmonary arterial pressure is increased and cardiac output remains unaltered. This indicates that the(More)
Adult bovine hemoglobin solutions were studied with respect to the influence of organic phosphates (adenosine-5'-triphosphate, 2,3-diphosphoglycerate, myo-inositolhexaphosphate) on the oxylabile proton binding (fixed-acid Haldane effect). At alkaline pH (less than 7.5) this Haldane effect is increased by organic phosphates, whereas at acid pH (less than(More)
Steady-state pulmonary diffusing capacity for CO and alveolar-arterial O2 pressure differences were measured at hypoxia in growing rats adapted to a simulated altitude of 3500 m. The pulmonary diffusing capacity was significantly higher and the alveolar-arterial gradients were significantly lower in the adapted animals as compared with the controls exposed(More)