Feodor Nielsen

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The EM algorithm (Dempster, Laird, and Rubin (1978)) is a much used tool for maximum likelihood estimation in missing or incomplete data problems. However, calculating the conditional expectation required in the E-step of the algorithm may be infeasible, especially when this expectation is a large sum or a high-dimensional integral. Instead an estimate of(More)
Many types of data are often incompletely observed. How incompletely is typically randomly determined. Heitjan and Rubin (Annals of Statistics (1991)) proposed a condition, \coarsened at random" or CAR, ensuring ig-norability of this randomness in discrete sample spaces. In general sample spaces CAR comes in two avors according to whether it is deened in(More)
A specific and sensitive method for the quantitation of quinidine, (3S)-3-hydroxyquinidine, quinidine N-oxide, and dihydroquinidine in plasma and urine has been developed. The method is based on a single-step, liquid-liquid extraction procedure, followed by isocratic reversed-phase high-performance liquid chromatography, with fluorescence detection. After(More)
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