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To determine whether the cardiovascular effect of 1,25(OH)(2)D is dependent on calcium and/or phosphorus, mice with targeted deletion of the 25(OH)D 1alpha-hydroxylase and their wild-type littermates were fed a normal diet or a diet to rescue the ambient serum calcium and phosphorus levels. Mice on the normal diet were treated daily with vehicle or(More)
OBJECTIVE Echocardiographic measurement of right ventricular function in patients with atrial septal defect (ASD) is challenging. The Doppler myocardial performance index (MPI) may provide a method of assessing function in these patients. The aim of this study was to evaluate right ventricular function and its changes after transcatheter closure in patients(More)
BACKGROUND Right ventricular (RV) volume overload is a well-known cardiac consequence of atrial septal defect (ASD) shunt, accounting for most of its long-term complications. Thus cardiac volumetric unloading is a major aim of transcatheter ASD closure. We set to study the right ventricular remodeling after transcatheter ASD closure in patients with(More)
PDGF-BB (Platelet-derived growth factor BB) and TGF-beta1(transforming growth factor beta1) are important growth factors in the modulation of vascular smooth muscle cell (VSMC) proliferation and PCNA (proliferating cell nuclear antigen) expression in VSMCs. PCNA expresses at a high level in proliferating cells. The present study aims to assess the effects(More)
U-Pb and Hf isotope analyses of zircons from felsic granulite xenoliths in Mesozoic volcanics reveal Early Archean ($3.6 Ga) lower crust beneath the younger (,2.85 Ga) southern margin of the North China craton, and suggest that the eastern part of the craton formed a coherent block by 3.6 Ga. Hf model ages indicate extraction of protoliths from the mantle(More)
The aim of the present study was to elaborate the underlying pathogenesis of laryngeal squamous cell carcinoma (LSCC). Micro (mi) RNA and messenger (m) RNA expression profiling of patients with LSCC were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs (DEMIs) and differentially expressed mRNAs (DEMs) were identified(More)
BACKGROUND Atrial septal defect (ASD) accounts for 10% of all congenital heart lesions and represent the third most congenital cardiac defect seen in adults. Atrial natriuretic peptide (ANP) is an important regulator of the sodium and volume homeostasis. This study was designed to investigate the changes in plasma ANP concentrations and three-dimensional(More)
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