Fengwei Zhu

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BACKGROUND Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome. We correlated increased AURKA-CN in mCRC tumours with KRAS mutation status, overall and progression-free survival (OS, PFS). METHODS Sixty-one mCRC tumours were analysed for AURKA-CN(More)
e14606 Background: Excision repair cross-complementing group 1 (ERCC1) plays a critical role in DNA repair and is associated with resistance to radiation and platinum-based therapy. RRM1 encodes the regulatory subunit of ribonucleotide reductase and is the molecular target of gemcitabine. We hypothesized that ERCC1 and RRM1 expression would predict for(More)
Hilgh Sensitivity and Specificity of PET/CT and Laparoscopic Diagnostic Lymph Node Excision for Lymph Node Metastases in Cervical Cancer Patients H. Hansen , A. Loft , A.K. Berthelsen , S. Lassen , C. Høgdall , S.A. Engelholm , Department of Radiation Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Department of Clinical(More)
To evaluate the efficacy and safety of a combination regimen of gefitinib and pemetrexed as first-line chemotherapy in advanced EGFR-mutated non-small cell lung cancer (NSCLC) patients. Patients and methods Patients with advanced non-squamous NSCLC harboring asensitive EGFR mutation were included in this study and randomly divided into gefitinib + placebo(More)
PURPOSE To investigate the status and distribution of epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (MET), and receptor tyrosine kinase (ROS1) genes in patients with non-small cell lung (NSCL) adenocarcinoma. METHODS The copy number of the MET gene was detected using fluorescence in situ hybridization (FISH). The splice(More)
376 Background: Few studies have evaluated disparities of race and SES with outcomes in RC patients. We hypothesize that disparities exist in treatment and outcomes of RC. METHODS Medical records were retrospectively reviewed of RC patients treated from 2000-2009 at an NCI cancer center and an urban academic center. SES was estimated using census data.(More)
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