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Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV‐Infected Macaques
Abstract The latent viral reservoir is the source of viral rebound after interruption of antiretroviral therapy (ART) and is the major obstacle in eradicating the latent human immunodeficiency… Expand
Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys
Though immune correlates for protection are still under investigation, potent cytotoxic T lymphocyte responses are desirable for an ideal HIV-1 vaccine. PD-1 blockade enhances SIV-specific CD8+ T… Expand
Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection.
Adenovirus serotype 5 (Ad5) is a common cause of respiratory tract infection, and populations worldwide have high prevalence of anti-Ad5 antibodies, implying extensively prior infection. Ad5… Expand
Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients.
Based on structure modification and a high-throughput Jurkat-Lat cell screening model, we found that GIBH-LRA002,… Expand
Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells
- F. Feng, J. Zhao, Pingchao Li, Ruiting Li, L. Chen, Caijun Sun
- Biology, Medicine
- 1 February 2019
Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus… Expand
Vaccination and immunotherapy of viral diseases (PP-069)
Research on the Design of Organizing Structure in Commodity Wholesale Markets
The organizing structure of commodity wholesale markets is the fundamental guarantee for the markets to create value. At present, there are many wholesale markets in our country which have the… Expand
Lung Memory B Cell Populations After Influenza Infection in Mice