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OBJECTIVE To evaluate the expression of ALDH1A1 in lung adenoma stem cells (LASCs) and maintenance of their stemness through the Notch pathway. METHODS LASCs (A549s) were isolated from lung adenoma cells (A549) and identified by their coexpression of CD133 and CD326 and their capacity formulti-directional differentiation. Expression of ALDH1A1 in A549 and(More)
We focus on the problem of large-scale near duplicate image retrieval. Recent studies have shown that local image features, often referred to as key points, are effective for near duplicate image retrieval. The most popular approach for key point based image matching is the clustering-based bag-of-words model. It maps each key point to a visual word in a(More)
Local image features, such as SIFT descriptors, have been shown to be effective for content-based image retrieval (CBIR). In order to achieve efficient image retrieval using local features, most existing approaches represent an image by a bag-of-words model in which every local feature is quantized into a visual word. Given the bag-of-words representation(More)
Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in(More)
Corneal nerves are mainly derived from the ophthalmic branch of the trigeminal ganglion (TG). Corneal neuropathy contributes to epithelial degenerative changes in diabetic keratopathy. Efficient drug delivery to TG may be beneficial for the treatment of diabetic keratopathy. This article described intranasal delivery of nanomicelle curcumin to correct(More)
A stable topical ophthalmic cyclosporine A (CsA) formulation with good tolerance and high efficacy is still a desire in pharmaceutics and clinics. This article describes the preparation of CsA containing nanomicelles using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer. Both the polymer itself and the CsA(More)
The aim of this study was to evaluate the contribution of mitochondrial DNA (mtDNA) mutations in oxidative phosphorylation (OXPHOS) deficiency. The complete mitochondrial genomes of 41 families with OXPHOS deficiency were screened for mutations. Mitochondrial functional analysis was then performed in primary and cybrid cells containing candidate mutations(More)
The purpose of the study was to investigate the impact of rat cytomegalovirus (RCMV) infection on the development of the nervous system in rat embryos, and to evaluate the involvement of Wnt signaling pathway key molecules and the downstream gene neurogenin 1 (Ngn1) in RCMV infected neural stem cells (NSCs). Infection and control groups were established,(More)
Bag-of-words model is one of the most widely used methods in the recent studies of multimedia data retrieval. The key idea of the bag-of-words model is to quantize the bag of local features, for example SIFT, to a histogram of visual words and then standard information retrieval technologies developed from text retrieval can be applied directly. Despite its(More)