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OBJECTIVE Ulcerative colitis (UC) is a widely studied inflammatory disease associated with differential expression of genes involved in immune function, wound healing, and tissue remodeling. MicroRNAs have been reported to play a role in various cancer types. However, the mechanism of how microRNAs regulate UC remains unclear. METHODS In the present(More)
OBJECTIVE While it's widely accepted that the etiology of ulcerative colitis (UC) involves both genetic and environmental factors, the pathogenesis of ulcerative colitis is still poorly understood. Intestinal epithelial apoptosis is one of the most common histopathological changes of UC and the expression of a number of apoptosis genes may contribute to the(More)
OBJECTIVE To investigate the therapeutic effect of Baitouweng Decoction on dextran sodium sulphate (DSS)-induced ulcerative colitis in mice and explore its mechanism involving miR-19a. METHODS Forty female c57 mice were randomly allocated into 4 equal groups, namely the normal control group, model group (treated with 3.5% DSS solution), treatment group(More)
Evidence-based studies are increasingly being focused on evaluating the efficacy and safety of adalimumab (ADA) for moderately to severely active ulcerative colitis (UC). However, the dosage pattern of ADA for UC management is still not clear. A meta-analysis was conducted to evaluate the efficacy and safety of different ADA dosage regimens for moderately(More)
OBJECTIVE To explore the application of factor analysis in creating a new health-related questionnaire for evaluating quality of life, the Chinese for Quality of Life Instrument (ChQOL). METHODS Two hundred and seventy-three subjects selected from two provinces of North China (Ningxia) and South China (Guangdong) were investigated by ChQOL, and the(More)
In order to clarify the binding site and orientation of H2O monomer on Fe(110) surfaces with different charges, the potential dependent adsorption of water monomer over charged Fe(110) surface has been studied using first principles method. The results indicate that H2O molecular prefers to special orientation on the surface with different charges. In(More)
Given its importance to the dynamics of cavitation bubbles, the mutual interaction between bubbles was carefully investigated in this work. The cavitation noises emitted in different sonication conditions were recorded to study the dynamical behavior of the bubbles. The frequency spectra of the noises suggest that the dispersing state of the bubbles(More)
By using scanning tunneling microscopy, the plots of tunneling current versus applied voltage, at the local points for hydrogenated and oxygenated chemical vapor deposited diamond films, were investigated. For comparison, the measurement points were adopted on the centers of the crystalline grains and at the grain boundaries, respectively. The results(More)
The electrochemical behaviors of different chlorophenols at boron-doped diamond thin film electrode were investigated. Four chlorophenols, the 2-chlorophenol (2-CP), 2,4-dichlorophenol (2,4-DCP), 2,4,6-trichlorophenol (2,4,6-TCP) and pentachlorophenol (PCP), with various number of chlorine atoms in the benzene rings, were studied by using cyclic voltammetry(More)