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TRAIL/Apo-2L is a member of the tumor necrosis factor superfamily and has recently been shown to induce apoptosis in cancer cells, but not in normal cells. In nude mice injected with human tumors, TRAIL reduces the size of these tumors without side effects. Akt promotes cell survival and block apoptosis. Some prostate cancer cells express high levels of Akt… (More)
Tumor necrosis factor superfamily member TRAIL/Apo-2L has recently been shown to induce apoptosis in transformed and cancer cells. Some prostate cancer cells express constitutively active Akt/protein kinase B due to a complete loss of lipid phosphatase PTEN gene, a negative regulator of phosphatidylinositol 3-kinase pathway. Constitutively active Akt… (More)
The positive real lemma provides the basis for constructing linear output feedback dynamic compensators for multi-input plants with independent amplitude saturations. Fixed-structure techniques are used to obtain full-and reduced-order feedback compensators along with a guaranteed domain of attraction. These results are then applied to the problem of rate… (More)
Since the proportional navigation guidance law was first introduced, many of the researchers had proposed different methodologies to investigate the corresponding performances of all the existing guidance laws. In 1997, Yang and Yang introduced an unified approach, in that paper the authors found that under the proposed framework, all the existing guidance… (More)
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SUMMARY In this paper we synthesize linear and nonlinear output feedback dynamic compensators for plants with saturating actuators. Our approach is direct in the sense that it accounts for the saturation nonlinearity throughout the design procedure as distinct from traditional design techniques that first obtain a linear controller for the 'unsaturated'… (More)
In this paper, we present a new guaranteed cost bound motivated by the maximum entropy equation. This bound is of interest due to its sensitivity to skew-symmetric structured uncertainty, which is difficult to address by means of conventional guaranteed cost bounds.