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Inspired by the attractive Flops/dollar ratio and the incredible growth in the speed of modern graphics processing units (GPUs), we propose to use a cluster of GPUs for high performance scientific computing. As an example application, we have developed a parallel flow simulation using the lattice Boltzmann model (LBM) on a GPU cluster and have simulated the(More)
We present our design and deployment experiences with LiveSky, a commercially deployed hybrid CDN-P2P live streaming system. CDNs and P2P systems are the common techniques used for live streaming, each having its own set of advantages and disadvantages. LiveSky inherits the best of both worlds: the quality control and reliability of a CDN and the inherent(More)
Although search engines are playing an increasingly important role in users' Web access, our understanding is still limited regarding the magnitude of search-engine influence. For example, how many times do people start browsing the Web from a search engine? How much percentage of Web traffic is incurred as a result of search? To what extent does a search(More)
Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels are among the mechanisms proposed by which astrocytes might release ATP; however, whether the gap junction protein connexin43 (Cx43) forms these "hemichannels" remains controversial. Recently, a new(More)
The vertebrate neural retina comprises six classes of neurons and one class of glial cells, all derived from a population of multipotent progenitors. There is little information on the molecular mechanisms governing the specification of cell type identity from multipotent progenitors in the developing retina. We report that Ptf1a, a basic-helix-loop-helix(More)
Pannexins are mammalian orthologs of innexins and have a predicted topological folding pattern similar to that of connexins, except they are glycosylated. Rat pannexin 1 is glycosylated at N254 and this residue is important for plasma membrane targeting. Here we demonstrate that cell surface expression levels of the rat pannexin 1 N254Q mutant are rescued(More)
The neurons generated at the germinal rhombic lip undergo long distance migration along divergent pathways to settle in widely dispersed locations within the hindbrain, giving rise to cerebellar granule cells and precerebellar nuclei. Neurotrophin-3 (NT-3) signaling has been shown to be required for proper migration and survival of cerebellar granule cells.(More)
We present the design and deployment experiences with <i>LiveSky</i>, a commercial hybrid CDN-P2P live streaming system, which inherits the best of both CDN and P2P. We address several key challenges, including: 1) ease of integration with existing CDN infrastructure, 2) dynamic resource scaling while guaranteeing quality-of-service, 3) providing good user(More)
We present an approach for simulating the natural dynamics that emerge from the interaction between a flow field and immersed objects. We model the flow field using the lattice Boltzmann model (LBM) with boundary conditions appropriate for moving objects and accelerate the computation on commodity graphics hardware (GPU) to achieve real-time performance.(More)