Feng-Pu Zhang

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BACKGROUND Rotigotine is a potent and selective D1, D2, and D3 dopaminergic receptor agonist. Due to an extensive first-pass effect, it has a very low oral bioavailability (approximately 0.5% in rats). PURPOSE The present investigation aimed to develop a microemulsion-based hydrogel for transdermal rotigotine delivery with lower application site(More)
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