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In order to make it possible to effectively represent deterministic uncertainties and vagueness as well as the human subjective observation and judgement inherent to many real-world problems, especially those in biomedicine, we introduce, in this paper, fuzzy states and fuzzy events and generalize (crisp) discrete event systems (DES) to fuzzy DES. The(More)
MOTIVATION Epigenetic modifications are one of the critical factors to regulate gene expression and genome function. Among different epigenetic modifications, the differential histone modification sites (DHMSs) are of great interest to study the dynamic nature of epigenetic and gene expression regulations among various cell types, stages or environmental(More)
MOTIVATION ChIP-seq is becoming the main approach to the genome-wide study of protein-DNA interactions and histone modifications. Existing informatics tools perform well to extract strong ChIP-enriched sites. However, two questions remain to be answered: (i) to which extent is a ChIP-seq experiment able to reveal the weak ChIP-enriched sites? (ii) are the(More)
BACKGROUND Gene expression microarrays are being used to develop new prognostic and predictive tests for breast cancer, and might be used at the same time to confirm oestrogen-receptor status and ERBB2 status. Our goal was to establish a new method to assign oestrogen receptor and ERBB2-receptor status to breast carcinoma based on mRNA expression measured(More)
The objective of this study was to determine the better method of myomectomy by comparing laparoscopic and open myomectomy for patients with fibroids with regard to operative parameters and outcomes. A systematic review was performed on published studies identified by the databases PubMed, EMBASE, the China Biological Medicine Datadase (CBMdisc), Ovid and(More)
In this note, we investigate the detectability problem in discrete event systems. We assume that we do not know initially which state the system is in. The problem is to determine the current and subsequent states of the system based on a sequence of observations. The observation includes partial event observation and/or partial state observation, which(More)
In this paper, we investigate opacity of discrete event systems. We define two types of opacities: strong opacity and weak opacity. Given a general observation mapping, a language is strongly opaque if all strings in the language are confused with some strings in another language and it is weakly opaque if some strings in the language are confused with some(More)