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Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo
Purpose: Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers and it is a common feature of prostate cancer. Thus, Stat3 represents aExpand
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p21-activated Kinase 6 (PAK6) Inhibits Prostate Cancer Growth via Phosphorylation of Androgen Receptor and Tumorigenic E3 Ligase Murine Double Minute-2 (Mdm2)*
  • T. Liu, Y. Li, +4 authors Feng Li
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 6 November 2012
Background: Deregulation of AR signaling may lead to prostate cancer. Results: PAK6 promotes AR ubiquitin-mediated degradation through phosphorylation of AR and Mdm2, resulting in inhibition ofExpand
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Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages.
Hyperglycaemia is a key factor in diabetic pathology. Macrophages are essential regulators of inflammation which can be classified into two major vectors of polarisation: classically activatedExpand
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Hyperlipemia and Oxidation of LDL Induce Vascular Smooth Muscle Cell Growth: An Effect Mediated by the HLH Factor Id3
Hyperlipemia and oxidized LDL (ox-LDL) are important independent cardiovascular risk factors. Ox-LDL has been shown to stimulate vascular smooth muscle cell (VSMC) proliferation. However, the effectsExpand
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Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
The causative progeria lamin A mutation inhibits CK2 enzyme activity to accelerate aging in laboratory mice. Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinaseExpand
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MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin.
Mounting evidence has shown that microRNAs (miRNAs) are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. Recent profile studies of miRNAExpand
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Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours
  • S. Li, Y. Zhang, +15 authors G. Nie
  • Chemistry, Medicine
  • Nature Biomedical Engineering
  • 24 July 2017
Limited intratumoural perfusion and nanoparticle retention remain major bottlenecks for the delivery of nanoparticle therapeutics into tumours. Here, we show that polymer–lipid–peptide nanoparticlesExpand
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Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice.
Protease-activated receptor-2 (PAR2) has been shown to play a key role in the pathophysiology of itch. However, the precise mechanism of PAR2-mediated itch remains largely unknown. In the presentExpand
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Tanshinone IIA and astragaloside IV promote the migration of mesenchymal stem cells by up-regulation of CXCR4
Mesenchymal stem cells (MSCs) have a therapeutic potential to treat cardiovascular diseases. However, a significant barrier to MSC therapy is insufficient MSC engraftment in ischemic myocardium afterExpand
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Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer.
As traditional anticancer treatments fail to significantly improve the prognoses, exploration of therapeutic modalities is urgently needed. Herein, a biomimetic magnetosome is constructed to favorExpand
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