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Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo
Purpose: Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers and it is a common feature of prostate cancer. Thus, Stat3 represents a… Expand
p21-activated Kinase 6 (PAK6) Inhibits Prostate Cancer Growth via Phosphorylation of Androgen Receptor and Tumorigenic E3 Ligase Murine Double Minute-2 (Mdm2)*
- T. Liu, Y. Li, +4 authors Feng Li
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 November 2012
Background: Deregulation of AR signaling may lead to prostate cancer. Results: PAK6 promotes AR ubiquitin-mediated degradation through phosphorylation of AR and Mdm2, resulting in inhibition of… Expand
Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages.
Hyperglycaemia is a key factor in diabetic pathology. Macrophages are essential regulators of inflammation which can be classified into two major vectors of polarisation: classically activated… Expand
Hyperlipemia and Oxidation of LDL Induce Vascular Smooth Muscle Cell Growth: An Effect Mediated by the HLH Factor Id3
Hyperlipemia and oxidized LDL (ox-LDL) are important independent cardiovascular risk factors. Ox-LDL has been shown to stimulate vascular smooth muscle cell (VSMC) proliferation. However, the effects… Expand
Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
The causative progeria lamin A mutation inhibits CK2 enzyme activity to accelerate aging in laboratory mice. Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinase… Expand
MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin.
- X. Wang, J. Chen, +4 authors Jia-ji Jiang
- Biology, Medicine
- Biochemical and biophysical research…
- 30 November 2012
Mounting evidence has shown that microRNAs (miRNAs) are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. Recent profile studies of miRNA… Expand
Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours
Limited intratumoural perfusion and nanoparticle retention remain major bottlenecks for the delivery of nanoparticle therapeutics into tumours. Here, we show that polymer–lipid–peptide nanoparticles… Expand
Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice.
- Yu Zhu, X. R. Wang, +9 authors J. H. Hu
- Chemistry, Medicine
- International immunopharmacology
- 1 October 2009
Protease-activated receptor-2 (PAR2) has been shown to play a key role in the pathophysiology of itch. However, the precise mechanism of PAR2-mediated itch remains largely unknown. In the present… Expand
Tanshinone IIA and astragaloside IV promote the migration of mesenchymal stem cells by up-regulation of CXCR4
Mesenchymal stem cells (MSCs) have a therapeutic potential to treat cardiovascular diseases. However, a significant barrier to MSC therapy is insufficient MSC engraftment in ischemic myocardium after… Expand
Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer.
As traditional anticancer treatments fail to significantly improve the prognoses, exploration of therapeutic modalities is urgently needed. Herein, a biomimetic magnetosome is constructed to favor… Expand