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University of Michigan for comments. The comments and suggestions of Bob Holthausen (the editor) and an anonymous referee greatly improved the paper. All errors remain my own. Abstract This paper examines the relationship between annual report readability and firm performance and earnings persistence. This is motivated by the Securities and Exchange(More)
This paper examines the tone and content of the forward-looking statements (FLS) in the Management Discussion and Analysis section (MD&A) of corporate 10-K and 10-Q filings using a Na¨ıve Bayesian machine learning algorithm. I first manually categorize 30,000 sentences of randomly-selected FLS extracted from the MD&As along two dimensions: (1) tone (i.e.,(More)
Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs from mouse fibroblasts requires a(More)
Association mapping can quickly and efficiently dissect complex agronomic traits. Rapeseed is one of the most economically important polyploid oil crops, although its genome sequence is not yet published. In this study, a recently developed 60K Brassica Infinium(®) SNP array was used to analyse an association panel with 472 accessions. The single-nucleotide(More)
In this study, we investigated a pattern-recognition technique based on an artificial neural network (ANN), which is called a massive training artificial neural network (MTANN), for reduction of false positives in computerized detection of lung nodules in low-dose computed tomography (CT) images. The MTANN consists of a modified multilayer ANN, which is(More)
For identification of genes responsible for varietal differences in flowering time and leaf morphological traits, we constructed a linkage map of Brassica rapa DNA markers including 170 EST-based markers, 12 SSR markers, and 59 BAC sequence-based markers, of which 151 are single nucleotide polymorphism (SNP) markers. By BLASTN, 223 markers were shown to(More)
Purpose – The purpose of this paper is to contribute to a growing body of research on cloud computing, by studying the small to medium-sized enterprise (SME) adoption process. If SMEs have access to scalable technologies they could potentially deliver products and services that in the past only large enterprises could deliver, flattening the competitive(More)
A central question in Alzheimer's disease concerns the mechanism by which beta-amyloid contributes to neuropathology, and in particular whether intracellular versus extracellular beta-amyloid plays a critical role. Alzheimer transgenic mouse studies demonstrate brain dysfunction, as beta-amyloid levels rise, months before the appearance of beta-amyloid(More)
Real-time search dictates that new contents be made available for search immediately following their creation. From the database perspective, this requirement may be quite easily met by creating an up-to-date index for the contents and measuring search quality by the time gap between insertion time and availability of the index. This approach, however,(More)
Content-based service, which dynamically routes and delivers events from sources to interested users, is extremely important to network services. However, existing content-based protocols for static networks will incur unaffordable maintenance costs if they are applied directly to the highly mobile environment that is featured in disruption-tolerant(More)