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Mitochondria play important roles in generation of free radicals, ATP formation, and in apoptosis. We studied the levels of mitochondrial electron transport chain (ETC) complexes, that is, complexes I, II, III, IV, and V, in brain tissue samples from the cerebellum and the frontal, parietal, occipital, and temporal cortices of subjects with autism and(More)
As one of the emerging algorithms in the field of artificial immune systems (AIS), the dendritic cell algorithm (DCA) has been successfully applied to a number of challenging real-world problems. However, one criticism is the lack of a formal definition, which could result in ambiguity for understanding the algorithm. Moreover, previous investigations have(More)
As an immune-inspired algorithm, the Dendritic Cell Algorithm (DCA), produces promising performance in the eld of anomaly detection. This paper presents the application of the DCA to a standard data set, the KDD 99 data set. The results of different implementation versions of the DCA, including antigen multiplier and moving time windows , are reported. The(More)
BACKGROUND Despite the seriousness of dengue-related disease, with an estimated 50-100 million cases of dengue fever and 250,000-500,000 cases of dengue hemorrhagic fever/dengue shock syndrome each year, a clear understanding of dengue pathogenesis remains elusive. Because of the lack of a disease model in animals and the complex immune interaction in(More)
BACKGROUND Dengue and Dengue hemorrhagic fever have emerged as some of the most important mosquito-borne viral diseases in the tropics. The mechanisms of pathogenesis of Dengue remain elusive. Recently, virus-induced apoptosis mediated by the Unfolded Protein Response (UPR) has been hypothesised to represent a crucial pathogenic event in viral infection. In(More)
In the present paper, we show that transport from early to late endosomes is inhibited at the restrictive temperature in a mutant CHO cell line (ldlF) with a ts-defect in epsilon coatomer protein (epsilonCOP), although internalization and recycling continue. Early endosomes then appear like clusters of thin tubules devoid of the typical multivesicular(More)
Wildfire propagation is a complex process influenced by many factors. Simulation models of wildfire spread, such as DEVS-FIRE, are important tools for studying fire behavior. This paper presents how the sequential Monte Carlo methods, i.e., particle filters, can work together with DEVS-FIRE for better simulation and prediction of wildfire. We define an(More)
Usher syndrome (USH) is a leading cause of deaf-blindness in autosomal recessive trait. Phenotypic and genetic heterogeneities in USH make molecular diagnosis much difficult. This is a pilot study aiming to develop an approach based on next-generation sequencing to determine the genetic defects in patients with USH or allied diseases precisely and(More)