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BACKGROUND We previously reported that immune activation in the spinal dorsal horn contributes to pain induced by chronic pancreatitis (CP). Targeting immune response in the CNS may provide effective treatments for CP-induced pain. Recent findings demonstrate that resolvin D1 (RvD1) can potently dampen inflammatory pain. We hypothesized that intrathecal(More)
1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) is a 5-HT(1A) agonist and was reported to display high affinity for serotonin (5-HT) receptor from the parasitic nematode Haemonchus contortus . The present investigation explored the possibility of using PAPP as a lead compound of new insecticides with novel mode of action. On the(More)
Fingerprint images are textural images consisting of ridges and valleys. The orientation of textures can be determined by orientation field computation. Fingerprint orientation field is the critical basis for fingerprint image segmentation, filtering enhancement and matching processes, and the fingerprint orientation field algorithm plays a very important(More)
The dynamic response of large space structures under accidental impact has been the subject of intense research since the occurrence of the 9/11 incident. In the present paper, using the 3D ANSYS/LS-DYNA, size effect and material property effect of the impactor on the damage modes of the single-layer Kiewitt-8 reticulated dome were investigated,(More)
A series of diacylhydrazine derivatives containing hydrophobic alkyl chains have been designed and synthesized. The target molecules have been identified on the basis of analytical spectral (IR, (1)H NMR, (13)C NMR, and HRMS) data. All synthesized compounds have been screened for their potential inhibition in vitro against chitin synthesis using yeast cell(More)
Acetylcholinesterase (AChE) and its mutation recently emerged as a significant research area, due to its resistance against organophosphate and carbamate insecticides. Residue G265, which is always a conservative residue, mutated to A265 is the most frequent mutant of AChE in Drosophila populations. However, only this mutation caused a 'butterfly effect'(More)