Felix K Weise

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Blood pressure, heart rate and heart rate variability (HRV) prior and during acute ethanol intoxication (0.7 g/kg) were studied in 8 healthy volunteers. Blood pressure and heart rate remained unaltered during intoxication. While HRV was significantly reduced immediately after ingestion (2P = 0.01). It is speculated that the reduction of HRV after heavy(More)
Diabetic cardiovascular autonomic neuropathy (CAN) has been directly characterized by reduced or absent myocardial [123I]metaiodobenzylguanidine (MIBG) uptake, but there is no information available on the relationship between the myocardial adrenergic innervation defects and long-term glycaemic control. In a prospective study over a mean of 4 years we(More)
1. An association has been reported between QT interval abnormalities and cardiovascular autonomic neuropathy in diabetic patients. The QT interval abnormalities reflect local inhomogeneities of ventricular recovery time and may be related to an imbalance in cardiac sympathetic innervation. Sympathetic innervation of the heart can be visualized and(More)
Heart rate variability (HRV) was studied in 11 chronic alcoholic subjects, 1-30 days after the beginning of abstinence and again 5, 12 and 24 weeks later. Two patients could be re-examined after 19 and 22 months, respectively. In the follow-up study, the total patient group showed a statistically significant increase in HRV with prolonged abstinence of at(More)
1. The purpose of this investigation was to determine non-invasively the changes in autonomic cardiovascular control observed in normal subjects submitted to acute cardiopulmonary blood volume expansion by 100 degrees head-down tilt. The effect of head-down tilt on finger blood pressure and heart rate fluctuations was studied by means of power spectral(More)
Measurement of heart rate variability was performed in 106 healthy volunteers and 31 alcoholics. The mean momentary arrhythmia (MMA) of normal individuals showed an exponential decrease with increasing age. Cardiac autonomic neuropathy was found in 5 of 31 alcoholics. In agreement with the concept of hyperexcitability the withdrawing alcoholics had a(More)
1. Non-invasive assessment of short-term systolic blood pressure (SBP) and heart rate (HR) variability was obtained with the plethysmographic finger blood pressure measurement device. Respiration was measured with a respiratory inductive plethysmograph, which was calibrated prior to each study. 2. The effects of breathing pattern on the respiratory (high(More)
The submembrane cytoskeletal meshwork of the axon contains the scaffolding protein betaIV-spectrin. It provides mechanical support for the axon and anchors membrane proteins. Quivering (qv(3j)) mice lack functional betaIV-spectrin and have reduced voltage-gated sodium channel (VGSC) immunoreactivity at the axon initial segment and nodes of Ranvier. Because(More)
The purpose of this investigation was to determine non-invasively the alteration in autonomic cardiovascular control observed in end-stage renal disease (ESRD) patients submitted to a hemodialysis (HD) treatment. The effect of HD on finger blood pressure (BP) and heart rate (HR) variability was studied by means of spectral analysis in 12 ESRD patients at(More)
Spectral analysis of heart rate variability (HRV) was used to assess the autonomic nervous control of cardiac function during orthostatic load in insulin-dependent diabetic patients and healthy subjects. The diabetic patients were divided into three groups: diabetics without neuropathy (group 1), diabetics with peripheral neuropathy (group 2), and diabetics(More)