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To compare efficacy and safety of a tigecycline regimen with an imipenem/cilastatin regimen in hospital-acquired pneumonia patients, a phase 3, multicenter, randomized, double-blind, study evaluated 945 patients. Coprimary end points were clinical response in clinically evaluable (CE) and clinical modified intent-to-treat (c-mITT) populations at(More)
BACKGROUND Dexmedetomidine (DEX) is a centrally acting alpha-2-adrenoceptor agonist that has potential in the management of alcohol withdrawal syndrome (AWS) owing to its ability to produce arousable sedation and to inhibit the adrenergic system without respiratory depression. The objective of this randomized controlled study was to evaluate whether(More)
The results of treatment of 590 patients are analyzed, to whom the operations on trachea were conducted. In 91 patient 99 complications have occurred, 35 (6.4%) patients died. But due to the operation method refinement, new approaches elaboration, improvement of the measures of tracheoplasty complications prophylaxis and treatment, 2 (1.4%) patients died of(More)
In 90 patients, to whom blood transfusion was done while the thoracic operation conduction, the blood hemoglobin (Hb) content was analysed. In the patients, to whom intraoperatively the blood preparations transfusion was done, Hb concentration in the blood was lower than in patients with similar blood loss, but who was not blood transfused. While the own(More)
Infectious complications developing in patients with chest traumas under prolonged artificial ventilation of lungs are described in the article, such as infection of respiration pathways, pneumonia, empyema of the pleura and sepsis. New methods for the treatment and prevention of such complications are presented.
Clinical data are presented on prolonged (3 to 63 days) nasotracheal intubation in 159 patients performed for controlled lung ventilation and for maintenance of upper respiratory ways patency in spontaneous respiration. The advantages and disadvantages of nasotracheal intubation as compared to tracheostomy and orotracheal intubation are analysed. The(More)
In 100 patients the highly-frequential (HF) artificial pulmonary ventilation (APV) was applied while conduction of reconstructive operation on trachea and its bifurcation. While application of two-pulmonary ventilation or single-pulmonary and part of another pulmonary ventilation using HF APV an adequate pulmonary gas exchange was guaranteed, but using of(More)