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The increasing discrepancy between the numbers of patients selected for cardiac transplantation and the available donor organs requires validation of markers of high risk at the time of initial evaluation that may help to determine which patients profit from aggressive therapy. We retrospectively examined the case records of 91 heart transplant candidates(More)
BACKGROUND In the early period after cardiac transplantation, differential diagnosis of graft failure due to rejection, infection, and other causes is important but difficult. METHODS In 22 consecutive patients undergoing heart transplantation, we prospectively determined levels of interleukin-6 as well as T-cell and monocyte subsets at eight points in(More)
BACKGROUND The aim of this study was to investigate coronary compliance in patients early and 71.8 weeks after orthotopic heart transplantation. METHODS Thirty patients (mean age 51.4 years, women n = 6) underwent coronary angiography early after orthotopic heart transplantation (mean interval 11.6 +/- 5.5 weeks), by which time 12 recipients had already(More)
BACKGROUND Retrograde diastolic blood flow in the proximal descending aorta (DAo) connecting complex plaques (≥4 mm thick) with brain-supplying supra-aortic arteries may constitute a source of stroke. Yet, data only from high-risk populations (cryptogenic stroke patients with aortic atheroma≥3 mm) regarding the prevalence of this potential stroke mechanism(More)
BACKGROUND/OBJECTIVES We examined the applicability of contrast-enhanced ultrasound (CEUS) for imaging of murine deep vein thrombosis (DVT) and measured the effects of enoxaparin, ticagrelor and P2Y(12) receptor deficiency in vivo. METHODS Deep vein thrombosis was induced by exposure to ferric chloride or ligation of the infrarenal vena cava of C57BL/6(More)
OBJECTIVES To evaluate targeting of a microbubble contrast agent to platelets under high shear flow using the natural selectin ligand sialyl Lewis. MATERIALS AND METHODS Biotinylated polyacrylamide Sialyl Lewis or biotinylated carbohydrate-free polymer (used as a control) were attached to biotinylated microbubbles via a streptavidin linker. Activated(More)
A 32-year-old woman presented to the emergency department after the sudden onset of palpitations, dyspnoea and left-sided tinnitus. Echocardiography revealed a ruptured aneurysm of the noncoronary sinus of Valsalva into the right atrium. Due to deterioration of right heart failure with rapidly progressive decline of systemic blood pressure, the patient(More)
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INTRODUCTION In western countries, the benefit of the Japanese extended D3 lymph node dissection in gastric cancer patients who have been operated on in curative intent has not been proven and higher rates of side effects are expected. The present matched-pair study retrospectively compared the new D3 method (1995-1999) with the historic D2 dissection(More)