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Many modeling and simulation tools have a lack of object orientation. So it is not possible to build true reusable components. Modelica is on the other hand a nice example of OO modeling language which can become a kind of international standard. In Modelica, a library which enables an efficient modeling in process technology, was implemented. All basic(More)
PURPOSE Prostate-specific antigen (PSA) doubling-time (PSA-DT) is an important indicator of progression and survival in men with prostate cancer. Three major limitations regarding PSA-DT determination may lead to inconsistent results: the variety of mathematical methods currently applied, the non-standardized handling of input variables and the potential(More)
With the progress in modeling dynamic systems new extensions in model coupling are needed. The models in classical engineering are described by differential equations. Depending on the general condition of the system the description of the model and thereby the state space is altered. This change of system behavior can be implemented in different ways. In(More)
BACKGROUND Hormone receptor expression can be quantified by computerized image analysis in immunohistochemically stained specimens. When comparing semiquantitative scoring with computerized image analysis a review of the literature shows contradictory findings concerning the correlation of these two methods. Recent technical approaches have been developed(More)
In health care the reimbursement of medical providers is an important topic and can influence the overall outcome. We present the agent-based GAP-DRG model, which allows a comparison of reimbursement schemes in outpatient care. It models patients and medical providers as agents. In the simulation patients develop medical problems (i.e., diseases) and a need(More)