Felix Breitenecker

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Many modeling and simulation tools have a lack of object orientation. So it is not possible to build true reusable components. Modelica is on the other hand a nice example of OO modeling language which can become a kind of international standard. In Modelica, a library which enables an efficient modeling in process technology, was implemented. All basic(More)
PURPOSE Prostate-specific antigen (PSA) doubling-time (PSA-DT) is an important indicator of progression and survival in men with prostate cancer. Three major limitations regarding PSA-DT determination may lead to inconsistent results: the variety of mathematical methods currently applied, the non-standardized handling of input variables and the potential(More)
To establish a qualitative and quantitative model of blood glucose response to stress hormone exposure, healthy subjects (HS) on and off somatostatin (250 micrograms/h) as well as insulin dependent diabetic patients were infused with either epinephrine (E), glucagon (G), cortisol (F), growth hormone (GH) or with a cocktail of these hormones raising plasma(More)
With the progress in modeling dynamic systems new extensions in model coupling are needed. The models in classical engineering are described by differential equations. Depending on the general condition of the system the description of the model and thereby the state space is altered. This change of system behavior can be implemented in different ways. In(More)
To elucidate the efficacy of continuous vs. intermittent exposure to epinephrine, phenylephrine, and insulin, hepatic glucose production was monitored in isolated perfused rat livers (means +/- SE, n = 6 each). To this end livers of fed rats were perfused with 5 mM glucose Krebs-Ringer buffer in a nonrecirculating system. Using this model it was shown that(More)
BACKGROUND Hormone receptor expression can be quantified by computerized image analysis in immunohistochemically stained specimens. When comparing semiquantitative scoring with computerized image analysis a review of the literature shows contradictory findings concerning the correlation of these two methods. Recent technical approaches have been developed(More)