Felix Behling

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BACKGROUND Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF(More)
OBJECTIVE Antiepileptic treatment of brain tumor patients mainly depends on the individual physician's choice rather than on well-defined predictive factors. We investigated the predictive value of defined clinical parameters to formulate a model of risk estimations for subpopulations of brain tumor patients. METHODS We enclosed 650 patients > 18 years of(More)
BACKGROUND The impact of prolonging temozolomide (TMZ) maintenance beyond six cycles in newly diagnosed glioblastoma (GBM) remains a topic of discussion. We investigated the effects of prolonged TMZ maintenance on progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS In this retrospective single-center cohort study, we included(More)
Dear Editor, We describe the case of a 36-year-old male with numerous hemangiomas limited to his right upper extremity. In the further course the treating angiologist suspected a neurocutaneous disorder and ordered a cranial MRI. It revealed a contrast-enhancing parenchymal lesion of the caudal cerebellum with a cystic aspect consistent with a(More)
AIMS Previous data suggest that expression of transcription factors FoxG1 and Olig-2 can separate hotspot H3F3A-mutant tumors in pediatric glioma. We evaluated their prognostic potential and feasibility for identifying H3F3A-mutant tumors among IDH-mutant/wildtype gliomas. METHODS Immunohistochemistry of FoxG1/Olig-2 and ATRX in 471 cases of diffuse(More)
OBJECTIVE Well-defined risk factors for the identification of patients with meningioma who might benefit from preoperative or early postoperative seizure prophylaxis are unknown. We investigated and quantified risk factors to determine individual risks of seizure occurrence in patients with meningioma. METHODS A total of 634 adult patients with meningioma(More)
OBJECTIVE Ventricular opening during glioblastoma (GBM) resection is controversial. Sufficient evidence regarding its prognostic role is missing. We investigated the impact of ventricular opening on overall survival (OS), hydrocephalus development, and postoperative morbidity in patients with GBM. METHODS Patients who underwent primary GBM resection(More)
OBJECTIVE To show that the combined use of intraoperative high-field MRI (iMRI) and electrophysiologic monitoring (IOM) is feasible, safe, and beneficial for patients. METHODS The setup, surgical, imaging, and clinical results of 110 patients with eloquent intracranial lesions with the combined use of 1.5T iMRI and IOM were analyzed. RESULTS 187 iMRI(More)