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L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide(More)
Physical exercise is a widely accepted behavioral strategy to enhance overall health, including mental function. However, there is controversial evidence showing brain mitochondrial dysfunction, oxidative damage and decreased neurotrophin levels after high-intensity exercise, which presumably worsens cognitive performance. Here we investigated learning and(More)
In many manufacturing plants, there is a major problem in the internal logistics due to the high number of products, machines, and routes, especially in those manufacturing plants that produce low weight products. For example, a manufacturer of plastic is used as a reference model. In this situation, the final product, storage boxes for home of various(More)