Felipe Sousa

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Several well-documented evolutionary processes are known to cause conflict between species-level phylogenies and gene-level phylogenies. Three of the most challenging processes for species tree inference are incomplete lineage sorting, hybridization and gene duplication, which may result in unwarranted comparisons of paralogous genes. Several existing(More)
An apparently hitherto undescribed, severe skeletal syndrome is reported in 3 siblings (2 boys, 1 girl) in a family of Turkish-Arabian descent. Major manifestations include; hypoplasia of the pelvis, congenital dislocation of the hip, severe bowing of femora, aplasia or hypoplasia of fibulae, absence or coalescence of tarsal bones, absence of various(More)
The identification of cancer stem cell (CSC) populations in virtually all tumor types has widespread clinical consequences. CSCs are suggested to be the only cells within malignancies endowed with tumorigenic capacity and are, therefore, directly implicated in therapy resistance and minimal residual disease. The genetic and molecular mechanisms sustaining(More)
E-ticketing systems for public transportation (ESPT) are an integral part of intelligent transportation systems (ITS) which shape the urban environment of the future. The wide deployment of ESPT around the world has proven its success and demonstrated large potential. However, till now the majority of such systems being in operation adhere to the specific(More)
The tic-toc-rhythm of the heart is defined as the rigid rhythm of the cardiac beat, which is not under the influence of respiration. This is a normal observation in infants but in children above the age of 1 year it is generally considered as a sign of rheumatic carditis. The tic-toc-rhythm which is measured on ECG tracings as an index of arrhythmia, shows(More)
Although hybridisation through genome duplication is well known, hybridisation without genome duplication (homoploid hybrid speciation, HHS) is not. Few well-documented cases have been reported. A possible instance of HHS in Medicago prostrata Jacq. was suggested previously, based on only two genes and one individual. We tested whether this species was(More)
Purpose: High expression of cancer stem cell (CSC) marker CD133 has been used as a predictor for prognosis in colorectal cancer (CRC), suggesting that enumeration of CSCs, using CD133, is predictive for disease progression. However, we showed recently that both CD133 mRNA and protein are not downregulated during differentiation of colon CSCs, pointing to an(More)
The concentration of alpha 1-antitrypsin in the serum of 64 neonates (36 prematures and 28 full term neonates) in the age group ranging from 2 hours to 6 days has been determined. A distinct connection was observed between the alpha 1-antitrypsin concentration and the disease of a primary disturbance of respiration (Respiratory Distress Syndrome). In(More)
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