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Recent animal work has suggested that cochlear synapses are more vulnerable than hair cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in conventional histopathological analysis, because cochlear nerve cell bodies in the spiral ganglion survive for years, and synaptic analysis requires special immunostaining or(More)
OBJECTIVE This study aimed to review the clinical history and management of patients with intralabyrinthine schwannomas and evaluate the histopathologic features of these tumors. STUDY DESIGN A retrospective case review of 24 patients and 7 temporal bone specimens. SETTING An otologic tertiary referral private practice. PATIENTS Patients with magnetic(More)
OBJECTIVE To describe results in a large series of patients using a recent variation of hypoglossal-facial nerve anastomosis (HFA) in which the intratemporal facial nerve segment is used, obviating the need for a sensory nerve "jump graft." STUDY DESIGN Retrospective chart review. SETTING Tertiary neurotologic referral center. PATIENTS Nineteen(More)
HYPOTHESIS It is possible to implant a stimulating electrode array in the semicircular canals without damaging rotational sensitivity or hearing. The electrodes will evoke robust and precisely controlled eye movements. BACKGROUND A number of groups are attempting to develop a neural prosthesis to ameliorate abnormal vestibular function. Animal studies(More)
IMPORTANCE There are limited data on the use of the supraclavicular artery island flap (SCAIF) for parotid and lateral skull base (LSB) surgery. This flap can be an important reconstructive tool for these procedures. OBJECTIVE To describe the use of the SCAIF for parotid and LSB surgery and its success, as well as important technique modifications for(More)
INTRODUCTION Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 µUI/mL), with normal free T4 and negative thyroid antibodies (AB). OBJECTIVE To recognize the risk of progression to Hashimoto's thyroiditis (HT). (More)
OBJECTIVE To describe the temporal bone histopathology in children with congenital toxoplasmosis. BACKGROUND Toxoplasmosis is a parasitic infection caused by Toxoplasma gondii. If fetal infection occurs early in gestation, severe inflammation and necrosis can cause brain lesions, chorioretinitis, and hearing loss. Hearing loss in congenital toxoplasmosis(More)
BACKGROUND Osteogenesis Imperfecta (OI) is a genetic disorder of connective tissue matrix. OI is caused by mutations that affect type I collagen. The hearing loss in OI is characterized by onset in early adulthood and can be conductive, sensorineural, or mixed. OBJECTIVES To describe the temporal bone histopathology in 9 individuals with OI. MATERIALS(More)
In this study was analysed the results of a group of patients with soft tissue sarcomas treated at the IPOFG Center of Lisbon from January 1979 to December 1988. All these cases were referred to the Radiotherapy Department for radiation treatment, which was given in 84% of the patients as a complement to surgery and in 16% was either combined with(More)