Felipe García

Montserrat Plana6
Teresa Gallart3
Agathe Leon3
Carmen Elena Gómez3
6Montserrat Plana
3Teresa Gallart
3Agathe Leon
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  • Marta Rodríguez-García, Núria Climent, Harold Oliva, Víctor Casanova, Rafael Franco, Agathe Leon +3 others
  • 2010
BACKGROUND Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce alpha-defensins1-3 and that alpha-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV(More)
  • Carmen Elena Gómez, José Luis Nájera, Beatriz Perdiguero, Juan García-Arriaza, Carlos Oscar S Sorzano, Victoria Jiménez +9 others
  • 2011
Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant(More)
  • Carlos del Fresno, Vanesa Gómez-Piña, Vanesa Lores, Alessandra Soares-Schanoski, Irene Fernández-Ruiz, Blas Rojo +8 others
  • 2008
Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the gene that codes for the chloride channel, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are frequently colonized by several pathogens, but the mechanisms that allow colonization in spite of apparently functional immune systems are(More)
  • Núria Climent, Susana Guerra, Felipe García, Cristina Rovira, Laia Miralles, Carmen Elena Gómez +5 others
  • 2011
Currently, MVA virus vectors carrying HIV-1 genes are being developed as HIV-1/AIDS prophylactic/therapeutic vaccines. Nevertheless, little is known about the impact of these vectors on human dendritic cells (DC) and their capacity to present HIV-1 antigens to human HIV-specific T cells. This study aimed to characterize the interaction of MVA and MVA(More)
OBJECTIVE In this article we will describe a new approach to improve the quality of care of chronic HIV/AIDS patients, combining the integral care approach with a telemedicine system. METHODS Following the integral care approach, we included the patient in a multidisciplinary care team, covering the whole process of care with a telemedicine system that(More)
INTRODUCTION Monotherapy with protease-inhibitors (MPI) may be an alternative to cART for HIV treatment. We assessed the impact of this strategy on immune activation, bacterial translocation and inflammation. METHODS We performed a cross-sectional study comparing patients on successful MPI (n=40) with patients on cART (n=20). Activation, senescence,(More)
  • Sergi Veloso, Montserrat Olona, Felipe García, Pere Domingo, Carlos Alonso-Villaverde, Montserrat Broch +12 others
  • 2010
Background: Tumor necrosis factor alpha (TNF-α) is thought to be involved in the various immunogenetic events that influence HIV-1 infection. Methods: We aimed to determine whether carriage of the TNF-α-238G>A,-308G>A and-863 C>A gene promoter single nucleotide polymorphisms (SNP) and the CCR5Δ32 variant allele influence the risk of HIV-1 infection and(More)
  • Carmen Álvarez-Fernández, Alberto Crespo Guardo, Javier García-Pérez, Felipe García, Julia Blanco, Laura Escribà-García +4 others
  • 2012
BACKGROUND The generation of new immunogens able to elicit strong specific immune responses remains a major challenge in the attempts to obtain a prophylactic or therapeutic vaccine against HIV/AIDS. We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and(More)
BACKGROUND Antiretroviral therapy has changed the natural history of human immunodeficiency virus (HIV) infection in developed countries, where it has become a chronic disease. This clinical scenario requires a new approach to simplify follow-up appointments and facilitate access to healthcare professionals. METHODOLOGY We developed a new internet-based(More)