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Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq
Background Schistosomiasis is one of the most prevalent parasitic diseases worldwide and is a public health problem. Schistosoma mansoni is the most widespread species responsible for schistosomiasisExpand
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Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions and development. However, its role in cancer is less well understood. Here, we show that RNF2, encoding RING1B, andExpand
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Targeted chemotherapy overcomes drug resistance in melanoma.
The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escapeExpand
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Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs.
Activating mutations in the mitogen-activated protein kinase (MAPK) cascade, also known as the RAS-MEK-extracellular signal-related kinase (ERK1/2) pathway, are an underlying cause of >70% of humanExpand
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Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1.
RNA 3' end processing provides a source of transcriptome diversification which affects various (patho)-physiological processes. A prime example is the transcript isoform switch that leads to theExpand
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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
SUMMARY Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, weExpand
High-quality draft genome sequence resources of eight Xylella fastidiosa strains isolated from citrus, coffee, plum and hibiscus in South America.
Xylella fastidiosa subsp. pauca , once confined to South America and infecting mainly citrus and coffee plants, has been found to be associated with other hosts and in other geographic regions. WeExpand
TAF1 plays a critical role in AML1-ETO driven leukemogenesis
AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein AssociatedExpand
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Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1
Integrator is a key regulator of NEAT1 isoform switching and, thereby, paraspeckles biogenesis and chemosensitivity. RNA 3′ end processing provides a source of transcriptome diversification whichExpand