Felipe A. Apablaza

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Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallmark of cellular aging, occurs in aged MSC. Whether MSC(More)
Th17 cells, a recently described subtype of CD4+ eff ector lymphocytes, have been linked to cell-mediated autoimmune and infl ammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defi ned. We therefore conducted the present study to evaluate IL-17A and Th17-related(More)
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