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The studies presented demonstrate changes in hypothalamo-pituitary-adrenocortical secretion, and in electrical activity and synaptic responses of neurons in the bed nucleus of the stria terminalis, preoptic area, and hypothalamic paraventricular nucleus of rats exposed to early, long-term social isolation. Rats isolated from all social contact from an early(More)
Diffusible factors, including netrins and semaphorins, are believed to be important cues for the formation of neural circuits in the forebrain. Here we have examined the role of netrin 1 in the development of hippocampal connections. We show that netrin 1 and its receptor, Dcc, are expressed in the developing fimbria and in projection neurons, respectively,(More)
We have studied the effects of long-term social isolation of male Wistar rats, after early weaning (16 days), on the activity of the hypothalamo-pituitary-adrenal (HPA) axis. In addition to studying basal HPA activity, the response of the HPA axis to 15 min of immobilization stress was examined. Plasma corticosterone concentrations were measured, and the(More)
Double-labeling immunohistochemical studies were performed to discern the morphological relationships between corticotropin-releasing factor-immunoreactive (CRF-ir) perikarya and afferent innervation in the hypothalamic paraventricular nucleus (PVN) of the rat. Attention was focussed on the local innervation by serotonin (5-hydroxytryptamine, 5-HT),(More)
The distribution and regulation of mRNA for the IGF-I receptor (IGF-I-R) in the adult rat brain were studied by in-situ hybridization with a 35S-labelled cRNA probe. The pituitary gland showed a strong hybridization signal in the pars tuberalis (the surface of the median eminence), pars distalis and pars intermedia. Within the brain, a strong hybridization(More)
This study was performed to characterize the effects of adrenalectomy (ADX) on electrical activity and synaptic responses of bed nucleus of the stria terminalis (BNST) and preoptic area (POA) neurons, which are involved in the control of limbic-hypothalamo-pituitary-adrenocortical (LHPA) activity. Adrenalectomy altered the response of BNST neurons to medial(More)
This paper analyses the idea of strong equivalence for transition systems represented as logic programs under the Answer Set Programming (ASP) paradigm. To check strong equivalence, we use a linear temporal extension of Equilibrium Logic (a logical characterisation of ASP) and its monotonic basis, the intermediate logic of Here-and-There (HT). Trivially,(More)
In this paper, we study a method for computing temporal equilibrium models, a generalisation of stable models for logic programs with temporal operators, as in Linear Temporal Logic (LTL). To this aim, we focus on a syntactic subclass of these temporal logic programs called splitable and whose main property is satisfying a kind of " future projected "(More)
This paper contains a survey of the main definitions and results obtained up to date related to Temporal Equilibrium Logic, a non-monotonic hybrid approach that combines Equilibrium Logic (the best-known logical characterisation for the stable models semantics of logic programs) with Linear-Time Temporal Logic.
Insulin-like growth factor I (IFG-I) was localized by light and electron microscopic immunocytochemistry in the adult rat cerebellum. Neurons showing the same cytological characteristics and pattern of synaptic input as Purkinje cells were IGF-I immunoreactive. In these neurons, intense electron-dense reaction product was consistently located in the rough(More)