Felicia Reid

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The discovery of monoclonal antibodies (mAbs) that bind to a particular molecular target is now regarded a routine exercise. However, the successful development of mAbs that (1) express well, (2) elicit a desirable biological effect upon binding, and (3) remain soluble and display low viscosity at high concentrations is often far more challenging.(More)
Self-interaction of an antibody may lead to aggregation, low solubility or high viscosity. Rapid identification of highly developable leads remains challenging, even though progress has been made with the introduction of techniques such as self-interaction chromatography (SIC) and cross-interaction chromatography (CIC). Here, we report a high throughput(More)
Advances in human antibody discovery have allowed for the selection of hundreds of high affinity antibodies against many therapeutically relevant targets. This has necessitated the development of reproducible, high throughput analytical techniques to characterize the output from these selections. Among these characterizations, epitopic coverage and affinity(More)
A study of moderate resolution (1 cm(-1)) atmospheric transmission measurements made over a 5.7-km path and under a wide range of temperatures and humidities is presented. A description of the Fourier interferometric transmissometer (FIT) used for this study and a detailed analysis of the experimental protocol developed for that type of instrument are(More)
In connection with a study at the Fixed Nitrogen Research Laboratory on the possible transformation products of cyanamid, there was obtained a number of materials and mixtures concerning which there is either very little known, or concerning which there is still some doubt as to their fertilizing value. Thus, in the preparation of urephos, a product was(More)
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