Felicia Maria Petrisor

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AIM The purpose of the present study was the analysis of the relationship between tumor necrosis factor-α (TNF-α) -308 G/A and cervical intraepithelial neoplasia (CIN). MATERIALS AND METHODS A prospective case-control study was performed, enrolling 78 cases of cervical intraepithelial neoplasia and 107 controls. Every patient had a complete gynecological(More)
DNA repair plays an important role in maintaining the integrity of the genome by repairing DNA damage induced by carcinogens. Certain genetic polymorphisms that occur in DNA-repair genes may affect the ability to repair DNA defects, and may represent a risk factor in carcinogenesis. The gene XRCC1 is involved in DNA repair. The purpose of our study was to(More)
Primary Open Angle Glaucoma (POAG) is a chronic, irreversible optic neuropathy leading to the progressive death of retinal ganglion cells, clinically observed as silent visual field loss along with a decrease in colour and contrast sensitivity. Multiple pathogenic theories have been issued and some of them have proven their involvement in disease(More)
Latest studies suggest that polymorphic DNA repair encoding genes could interfere with the etiopathogeny and therefore individual susceptibility to develop lung cancer. Because ERCC2/XPD gene is generally involved in carcinogenesis, certain mutant polymorphism might be important risk factors in exposure to carcinogens. The purpose of this case-control study(More)
Low dietary folate intake has been blamed for many pathologies including cancers, thrombophilia, congenital anomalies (e.g. neural tube defects) and recurrent spontaneous abortions (RSA). An important biological function of folates, which is closely related to homocysteine levels, is to provide methyl groups, which are essential for DNA methylation(More)
Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled(More)
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