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Deep clinical and neuropathological phenotyping of Pick disease
To characterize sequential patterns of regional neuropathology and clinical symptoms in a well‐characterized cohort of 21 patients with autopsy‐confirmed Pick disease.
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c-Src/Cav1-dependent activation of the EGFR by Dsg2
The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human cancers including those of the skin. When ectopically expressed in the epidermis of transgenic mice, Dsg2 activatesExpand
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Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes
  • M. Lewis, G. Du, +9 authors X. Huang
  • Psychology, Medicine
  • Movement disorders : official journal of the…
  • 1 September 2018
Background: Parkinsonisms are neurodegenerative disorders characterized pathologically by α‐synuclein‐positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau‐positive (e.g., PSP, corticalExpand
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Semi-Automated Digital Image Analysis of Pick’s Disease and TDP-43 Proteinopathy
Digital image analysis of histology sections provides reliable, high-throughput methods for neuropathological studies but data is scant in frontotemporal lobar degeneration (FTLD), which has an addedExpand
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Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion.
In addition to playing a role in adhesion, desmoglein 2 (Dsg2) is an important regulator of growth and survival signaling pathways, cell proliferation, migration and invasion, and oncogenesis.Expand
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Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression.
Activation of the hedgehog pathway is causative of virtually all sporadic and Gorlin syndrome-related basal cell carcinomas (BCCs), with loss of function of Ptc1 being the most common genomic lesion.Expand
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078 Dsg2 enhances spontaneous BCC formation in Ptc1+/− mice
S | Carcinogenesis & Cancer Genetics 074 Bullous leukemia cutis in a patient with T-cell prolymphocytic leukemia Q Jiang, S Siu, S Onder Alpdogan, A Gochoco, J Gong, J Lee and J Sahu 1 Dermatology,Expand