Felice Giuliante

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In their nice study on serum total antioxidant capacity (TAC) in sepsis [1] Chuang and coworkers have demonstrated an increase in TAC that was directly correlated to severity of illness and poor outcome, and to increasing levels of serum uric acid (UA). Although the increase in TAC might be interpreted as an extreme protective attempt against overwhelming(More)
We have previously reported that neoadjuvant therapy with modified FOLFIRI enabled nearly a third of patients with metastatic colorectal cancer (mCRC) to undergo surgical resection of liver metastases. Here, we present data from the long-term follow-up of these patients. Forty patients received modified FOLFIRI: irinotecan 180 mg m(-2), day 1; folinic acid,(More)
This study was performed to provide simplified quantitative evidence of the impact of hemoglobin concentration on blood CO(2) binding and transport capacity. Linear regression equations were obtained for gas analyses data obtained from 85 surgical patients with sepsis and various degrees of illness. Venoarterial CO(2) concentration differences were(More)
Albeit a very large number of experiments have assessed the impact of various substrates on liver regeneration after partial hepatectomy, a limited number of clinical studies have evaluated artificial nutrition in liver resection patients. This is a peculiar topic because many patients do not need artificial nutrition, while several patients need it because(More)
The response rate of patients with unresectable liver-limited metastases of colorectal cancer can be improved by converting inoperable disease to operable disease. However, the benefits of conversion chemotherapy for survival are still controversial. Patients considered to have technically inoperable disease by a multidisciplinary team were retrospectively(More)
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures of mucin- and mixed-IHCCA were prepared from surgical specimens (N. 18 IHCCA patients) and evaluated for cell proliferation (MTS assay) and apoptosis (Caspase 3) after incubation (72 hours) with increasing(More)
We appreciated the article by Gonnert and colleagues on hyperbilirubinemia from septic hepatocellular excretory dysfunction [1], a still improperly characterized issue in clinical settings. We address postoperative liver resection patients with prominently conjugated (~50 to 70 % conjugated) hyperbilirubinemia. Less relevant causes include transient(More)
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