Feiyang Liu

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Numerous lines of evidence suggest a strong link between diabetes mellitus and Alzheimer's disease (AD). Impaired insulin signaling and insulin resistance occur not only in diabetes but also in the brain of AD. Recent evidence has indicated that peroxisome proliferator-activated receptor γ (PPARγ) agonists thiazolidinediones (TZDs) can decrease β-amyloid(More)
Available online xxxx a b s t r a c t Network-on-Chip (NoC) replaces the traditional bus-based architecture to become the mainstream design methodology for future complex System-on-Chip (SoC). It introduces the principles of packet switching and interconnection network into SoC design, and achieves much better performance for its high bandwidth,(More)
The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery of a potent and selective DDR1 inhibitor, DDR1-IN-1, and present the 2.2 Å DDR1 co-crystal structure. DDR1-IN-1 binds to DDR1 in the(More)
OBJECTIVES Tyrosine kinase inhibitor (TKI)-treated acute myeloid leukemia (AML) patients commonly show rapid and significant peripheral blood blast cell reduction, however a marginal decrease in bone marrow blasts. This suggests a protective environment and highlights the demand for a better understanding of stromal:leukemia cell communication. As a(More)
BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys481.(More)
PI3Kδ is predominately expressed in leukocytes and has been found overexpressed in B-cell related malignances such as CLL and AML. We have discovered a highly selective ATP competitive PI3Kd inhibitor PI3KD-IN-015, which exhibits a high selectivity among other PI3K isoforms in both biochemical assays and cellular assay, meanwhile did not inhibit most of(More)
The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance mechanisms in the AML refractory patients involves(More)
Delay Tolerant Network (DTN) is a promising technology which aims to provide efficient communication between devices in a network with no guaranteed continuous connectivity. Most of the existing routing schemes for DTNs achieve message delivery through message replication and forwarding. However, due to the lack of contemporaneous end-to-end communication(More)
Delay Tolerant Networking (DTN) is a promising technology that aims to provide efficient communication between devices in a network with no guaranteed continuous connectivity. Most existing routing schemes for DTNs exploit the advantage of message replication to achieve high message delivery rate. However, these schemes commonly suffer from large(More)