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The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma.
TLDR
It is suggested that PA significantly suppressed airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma.
In vivo hypoglycemic effects of phenolics from the root bark of Morus alba.
Moracin M (1), Steppogenin-4'-O-beta-D-glucosiade (2), Mullberroside A (3) were isolated from the root bark of Morus alba L. and identified by spectral evidence. Compounds 1, 2 and 3 were studied in
Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation.
TLDR
CPPD can significantly suppress OVA-induced airway inflammation, airway hyperreactivity and Th2 predominant response in mice, showing great therapeutic potential for the treatment of allergic asthma.
Phenolic Compounds from Clinopodium chinense (Benth.) O. Kuntze and Their Inhibitory Effects on α‐Glucosidase and Vascular Endothelial Cells Injury
TLDR
Results suggest that the 14 bioactive constituents were responsible for hypoglycemic and protective vascular endothelium effect of C. chinense (Benth.) O. Kuntze.
Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn.
Abstract Aim To study the chemical components of the seeds of Caesalpinia sappan. Methods Compounds were isolated and purified by column chromatography. Their structures were elucidated on the basis
Ethyl Rosmarinate Protects High Glucose-Induced Injury in Human Endothelial Cells
TLDR
The results suggested that RAE protected endothelial cells from high glucose-induced apoptosis by alleviating reactive oxygen species (ROS) generation, and regulating the PI3K/Akt/Bcl-2 pathway, the NF-κB pathway, and the JNK pathway.
[Studies on anti-hyperglycemic effect and its mechanism of Clinopodium chinense].
TLDR
The results suggest that EJCT can significantly attenuate hyperglycemia in diabetic mice, which is probably due to decreasing the decomposition of liver glucogen, increasing the synthesis of liver glucose, antioxidation and amelioration of damaged pancreatic islet.
Hypoglycemic Effect of Ethanol and Ethyl Acetate Extract of Phellinus baumii Fruiting Body in Streptozotocin-Induced Diabetic Mice
TLDR
Taken together, AcOEt and EtOH extracts of P. baumii fruiting body exhibited considerable hypoglycemic effect on STZ-induced diabetic mice.
A new ellagic acid derivative from Polygonum runcinatum
TLDR
A new ellagic acid derivative, 3,3′-dimethylellagic acid-4′-O-(6″-galloyl)-β-d-glucoside, named runcinatside, together with four known compounds, showed antioxidant activities in vitro and compound 5 possessed the highest activity.
A new β-carboline alkaloid from the seeds of Griffonia simplicifolia.
TLDR
A new β-carboline alkaloid is new and was named griffonine, together with seven known alkaloids, which showed growth inhibitory effects on the HepG2 cell line and were potentially cytotoxic.
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