Fei-fei Feng

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Nanostructured lipid carriers (NLC) are a new generation of lipid nanoparticles, which are produced by controlled mixing of solid lipids with spatially incompatible liquid lipids leading to special nanostructures with improved drug incorporation and release properties. In this study, silybin-loaded nanostructured lipid carriers with various liquid lipid(More)
Recently, animal fatty acid synthase (FASN) is reported as a potential therapeutic target for obesity and cancer. Considerable interest has been developed in searching for novel inhibitors of this enzyme. An extract from Pangdahai has been found to inhibit FASN in both reversible and irreversible manners, with an IC(50) of 3.5 microg/ml and an apparent(More)
OBJECTIVE To study the effects of monocyte-macrophages (THP-1) in malignant transformation of human bronchial epithelial cells (BEAS-2B) cells induced by coal tar pitch (CTP) and the expression of TNF-α in the process of the cell malignant transformation. METHODS BEAS-2B cells and THP-1 Cells were divided into four groups: coal tar pitch (CTP) group,(More)
OBJECTIVE To explore the TGF-beta1, PDGF, CTGF serum expression significance in the occurrence and development of pneumoconiosis. METHODS The serum levels of TGF-beta1, PDGF, CTGF in 70 patients with pneumoconiosis (including 29 patients with silicosis and 41 patients with coal pneumoconiosis) and 77 healthy individuals were detected by means of enzyme(More)
OBJECTIVE To study which classification model was most suitable for establishing a multi-tumor markers lung cancer prediction model, through established logistic regression model, decision trees model and artificial neural network model. METHODS RIA analysis, ELISA, spectrophotometry, high-performance liquid chromatography (HPLC) and atomic absorption(More)
The mechanism for anti-tumor activity of oridonin (ORI) nanosuspension, prepared by the high pressure homogenization method, was studied using MCF-7 human breast carcinoma cells in vitro. MTT assay, observation of morphologic changes, flow cytometric analysis, and western blot analysis indicated that ORI nanosuspension could significantly intensify the in(More)
BACKGROUND We sought to evaluate the role of tumor associated macrophages (TAMs) on the promotion of coal tar pitch extract (CTPE)-induced tumorigenesis of human bronchial epithelial cells (BEAS-2B) and tumor metastasis in nude mice, and related mechanisms. MATERIALS AND METHODS BEAS-2B cells were first treated with 2.4 mg/mL CTPE for 72 hours. After(More)
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