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Recently, the Institute of Automation of Chinese Academy of Sciences (CASIA) released the uncon-strained online and offline Chinese handwriting databases CASIA-OLHWDB and CASIA-HWDB, which contain isolated character samples and handwritten texts produced by 1020 writers. This paper presents our benchmarking results using state-of-the-art methods on the(More)
In the Chinese handwriting recognition competition organized with the ICDAR 2011, four tasks were evaluated: offline and online isolated character recognition, offline and online handwritten text recognition. To enable the training of recognition systems, we announced the large databases CASIA-HWDB/OLHWDB. The submitted systems were evaluated on un-open(More)
Microglia plays important role in central nervous system immune surveillance and has emerged as an essential cellular component for understanding brain diseases. MicroRNAs (miRs) are small, noncoding RNAs that regulate the post-transcriptional expression of protein-coding mRNAs, which may have key roles in microglial activation in response to brain ischemia(More)
—This paper introduces a pair of online and offline Chinese handwriting databases, containing samples of isolated characters and handwritten texts. The samples were produced by 1,020 writers using Anoto pen on papers for obtaining both online trajectory data and offline images. Both the online samples and offline samples are divided into six datasets, three(More)
Mesial temporal lobe epilepsy (MTLE) is a particularly devastating form of human epilepsy with significant incidence of medical intractability. MicroRNAs (miRs) are small, noncoding RNAs that regulate the posttranscriptional expression of protein-coding mRNAs, which may have key roles in the pathogenesis of MTLE development. To study the dynamic expression(More)
Recently, the role of inflammation has attracted great attention in the pathogenesis of mesial temporal lobe epilepsy (MTLE), and microRNAs start to emerge as promising new players in MTLE pathogenesis. In this study, we investigated the dynamic expression patterns of tumor necrosis factor alpha (TNF-α) and microRNA-155 (miR-155) in the hippocampi of an(More)
This paper presents an effective approach for the offline recognition of unconstrained handwritten Chinese texts. Under the general integrated segmentation-and-recognition framework with character oversegmentation, we investigate three important issues: candidate path evaluation, path search, and parameter estimation. For path evaluation, we combine(More)
Our previous studies have shown that geniposide plays an essential role in glucose-stimulated insulin secretion from pancreatic β cells and also antagonizesAβ1-42-induced cytotoxicity examined using a primary cortical neuron assay. However, the mechanism by which geniposide appears to regulate insulin signaling in the brain is presently not well understood.(More)