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Recently, the Institute of Automation of Chinese Academy of Sciences (CASIA) released the uncon-strained online and offline Chinese handwriting databases CASIA-OLHWDB and CASIA-HWDB, which contain isolated character samples and handwritten texts produced by 1020 writers. This paper presents our benchmarking results using state-of-the-art methods on the(More)
In the Chinese handwriting recognition competition organized with the ICDAR 2011, four tasks were evaluated: offline and online isolated character recognition, offline and online handwritten text recognition. To enable the training of recognition systems, we announced the large databases CASIA-HWDB/OLHWDB. The submitted systems were evaluated on un-open(More)
Astrocyte activation, associated with the release of pro-inflammatory cytokines interleukin 1-β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), is a hallmark of multiple brain diseases, including mesial temporal lobe epilepsy. In recent years, several microRNAs have emerged as important controllers of Toll-like receptor (TLR)(More)
Microglia plays important role in central nervous system immune surveillance and has emerged as an essential cellular component for understanding brain diseases. MicroRNAs (miRs) are small, noncoding RNAs that regulate the post-transcriptional expression of protein-coding mRNAs, which may have key roles in microglial activation in response to brain ischemia(More)
BACKGROUND Mutations in the cardiac Na(+) channel gene (SCN5A) can adversely affect electric function in the heart, but effects can be age dependent. We explored the interacting effects of Scn5a disruption and aging on the pathogenesis of sinus node dysfunction in a heterozygous Scn5a knockout (Scn5a(+/-)) mouse model. METHODS AND RESULTS We compared(More)
—This paper introduces a pair of online and offline Chinese handwriting databases, containing samples of isolated characters and handwritten texts. The samples were produced by 1,020 writers using Anoto pen on papers for obtaining both online trajectory data and offline images. Both the online samples and offline samples are divided into six datasets, three(More)
The emerging data show that the insulinotrophic hormone glucagon-like peptide-1(GLP-1) and its agonist extendin-4 have neurotrophic function to inducing neuronal differentiation of PC12 cells and prevent neurons damage challenged by oxidative stress. Here, with the model of high throughput screen for GLP-1 receptor agonists, we screen and identify that(More)
Recently, the role of inflammation has attracted great attention in the pathogenesis of mesial temporal lobe epilepsy (MTLE), and microRNAs start to emerge as promising new players in MTLE pathogenesis. In this study, we investigated the dynamic expression patterns of tumor necrosis factor alpha (TNF-α) and microRNA-155 (miR-155) in the hippocampi of an(More)
Expression of the RCAN1 gene can be induced by multiple stresses. RCAN1 proteins (RCAN1s) have both protective and harmful effects and are implicated in common human pathologies. The mechanisms by which RCAN1s function, however, remain poorly understood. We identify RCAN1s as regulators of mitochondrial autophagy (mitophagy) and demonstrate that induction(More)