Learn More
BACKGROUND Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts(More)
In attempts to develop a method of introducing DNA into Pyrococcus furiosus, we discovered a variant within the wild-type population that is naturally and efficiently competent for DNA uptake. A pyrF gene deletion mutant was constructed in the genome, and the combined transformation and recombination frequencies of this strain allowed marker replacement by(More)
A Reverse k-Nearest-Neighbor (RkNN) query finds the objects that take the query object as one of their k nearest neighbors. In this paper we propose new solutions for evaluating RkNN queries and its variant bichromatic RkNN queries on 2-dimensional location data. We present an algorithm named INCH that can compute a RkNN query's search region (from which(More)
We developed a natural, acellular, 3-D interconnected porous scaffold derived from cartilage extracellular matrix (ECM). Human cartilage was physically shattered, then decellularized sequentially with use of hypotonic buffer, TritonX-100, and a nuclease solution and made into a suspension. The scaffold was fabricated by simple freeze-drying and(More)
Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level. However, little is known about the potential and mechanism of glycinergic cannabinoids for chronic pain treatment. We report that systemic and intrathecal administration of cannabidiol (CBD), a major(More)
OBJECTIVES We sought to determine whether drug-eluting stents (DES) were associated with improved clinical outcomes compared with bare-metal stents (BMS) among a nationally representative, nonexperimental elderly patient cohort. BACKGROUND Randomized controlled clinical trials comparing DES and BMS for treatment of coronary artery disease indicate that(More)
This paper introduces an efficient algorithm for the compressed MR image reconstruction problem, which is formulated as the minimization of a linear combination of three terms corresponding to a least square data fitting, nonlocal total variation (NLTV) and wavelet sparsity regularization. In our method, the original minimization problem is decomposed into(More)
Cadmium (Cd) is a common environmental pollutant, and urinary Cd (UCd) is generally used as a marker of exposure; however, our understanding on the related urinary metabolic changes caused by Cd exposure is still not clear. In this study, we applied a mass-spectrometry-based metabolomic approach to assess the urinary metabolic changes in human with(More)
BACKGROUND In humans, chromosome fragile sites are regions that are especially prone to forming non-staining gaps, constrictions or breaks in one or both of the chromatids on metaphase chromosomes either spontaneously or following partial inhibition of DNA synthesis and have been well identified. So far, no plant chromosome fragile sites similar to those in(More)
OBJECTIVE To compare operative time, safety and effectiveness of minimally invasive percutaneous nephrolithotomy (MPCNL) in the supine lithotomy versus prone position. METHODS Between January 2008 and December 2010, a total of 109 consecutive patients with upper urinary tract calculi were enrolled and randomly divided into group A (53 patients, supine(More)