Fei Hou

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PURPOSE To investigate the impact of Pro370Leu mutant myocilin on endoplasmic reticulum (ER) stress response and mitochondria function in human trabecular meshwork (HTM) cells. METHODS HTM cells were transfected with wild-type Pro370Leu mutant myocilin or pcDNA3.1 (+) expression plasmids. The effect of the mutant myocilin on ER stress response was(More)
Real-time and realistic physics-based simulation of deformable objects is of great value to medical intervention, training, and planning in virtual environments. This paper advocates a virtual-reality (VR) approach to minimally-invasive surgery/therapy (e.g., percutaneous coronary intervention) in medical procedures. In particular, we devise a robust and(More)
This paper presents a novel modeling framework to build 3D models of Chinese architectures from elevation drawing. Our algorithm integrates the capability of automatic drawing recognition with powerful procedural modeling to extract production rules from elevation drawing. First, different from the previous symbol-based floor plan recognition, based on the(More)
PURPOSE Patients reproduce symptoms of primary open-angle glaucoma (POAG) when treated with glucocorticoids (GCs) topically on the eyes. Here we investigated the effects of GCs on junctional protein expression and cytoskeleton organization in primary human trabecular meshwork (TM) cultures to understand the molecular pathologies of POAG. METHODS Human TM(More)
Active Hobo/Activator/Tam3 (hAT) transposable elements are rarely found in vertebrates. Previously, goldfish Tgf2 was found to be an autonomously active vertebrate transposon that is efficient at gene-transfer in teleost fish. However, little is known about Tgf2 functional domains required for transposition. To explore this, we first predicted in silico a(More)
This paper advocates a novel method for modelling physically realistic flow from captured incompressible gas sequence via modal analysis in frequency-constrained subspace. Our analytical tool is uniquely founded upon empirical mode decomposition (EMD) and modal reduction for fluids, which are seamlessly integrated towards a powerful, style-controllable flow(More)
Increased fibronectin (FN) expression has an important role during liver fibrosis. The present study examined FN expression in rats subjected to carbon tetrachloride (CCl4)‑induced liver fibrosis. In addition, the potential mechanisms underlying fibrogenesis were investigated by exposing hepatic stellate cells (HSCs) to transforming growth factor‑β (TGF‑β),(More)
This paper advocates a new component-aware framework to reconstruct 3D architecture from a single image. Different from existing work, our motivation is to obtain a complete set of semantically correct 3D architectural components, which enables part reusability towards rapid model reproduction and facilitates model variation. The core of our system is a(More)