Fei Fu

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The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to identify small-molecule enhancers of rapamycin (SMERs) and discovered an inhibitor (SMER3) of the(More)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control 1. With prevalent hyper-activation of the mTOR pathway in human cancers 2 , novel strategies to enhance Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions(More)
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