Federico Focher

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DNA repair mechanisms usually consist of a complex network of enzymatic reactions catalyzed by a large family of mutually interacting gene products. Thus deficiency, alteration or low levels of a single enzyme and/or of auxiliary proteins might impair a repair process. There are several indications suggesting that some enzymes involved both in DNA(More)
Review Protein–protein interactions in intracellular Ca 2 +-release channel function by J.J. Mackrill 345–361 Research Papers Proteins A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants : abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in(More)
By a rapid PCR-based method to assess the 8344 mtDNA mutation associated with MERRF disease, we have studied DNA from blood samples of 10 individuals belonging to a family spanning four generations in which one patient showed the complete MERRF phenotype, three other members were less severely affected, while the remaining were unaffected. The percentage of(More)
2-Phenylamino-6-oxo-9-(4-hydroxybutyl)purine (HBPG) is a thymidine kinase inhibitor that prevents encephalitic death in mice caused by herpes simplex virus (HSV) types 1 and 2, although its potency is somewhat less than that of acyclovir (ACV). The present study was undertaken to determine the effect of combinations of HBPG and either ACV, phosphonoformate(More)
Neuronal aging and abiotrophy may be related to the abnormal presence of uracil in DNA. Evidence which could support this hypothesis exists: 1) DNA polymerase beta, the only nuclear DNA polymerase present in adult neurons which is able to repair damaged DNA, incorporates dUTP or dTTP with the same efficiency. This suggests that in adult neurons the(More)
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. A single nucleotide polymorphism Ϫ1131TϾC in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride(More)
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen? Localization of xanthine dehydrogenase mRNA in horse skeletal muscle by in situ(More)
Emergence of drug-resistant Plasmodium falciparum has created an urgent need for new drug targets. DNA polymerase δ is an essential enzyme required for chromosomal DNA replication and repair, and therefore may be a potential target for anti-malarial drug development. However, little is known of the characteristics and function of this P. falciparum enzyme.(More)
A pioneering study in 'human genetics' and the evolutionary aspects present in his revival of epigenetic theory should rank the French philosopher Pierre-Louis Moreau de Maupertuis (1698–1759) among the great forerunners of genetics and evolution. Could one not explain by that means [the fortuitous appearance of mutant 'particles'] how from two individuals(More)
The Tole of lysine-67 in a class C fl-lactamase is mainly electrostatic Receptor-mediated Mn2+ influx in rat hepatocytes: comparison of cells loaded with Fura-2 ester and cells microinjected with Fura-2 salt Cloning of cDNA encoding the bifunctional dehydroquinase-shikimate dehydrogenase of aromatic-amino-acid biosynthesis in Nicotiana tabacum Research(More)
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