Federico Buti

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Many biological phenomena are inherently multiscale, i.e. they are characterised by interactions involving different scales at the same time. This is the case of bone remodelling, where macroscopic behaviour (at organ and tissue scale) and microstructure (at cell scale) strongly influence each other. Consequently, several approaches have been defined to(More)
We define an individual-based probabilistic model of a sole (Solea solea) behaviour. The individual model is given in terms of an Extended Probabilistic Discrete Timed Automaton (EPDTA), a new formalism that is introduced in the paper and that is shown to be interpretable as a Markov decision process. A given EPDTA model can be probabilistically(More)
Existing approaches in multiscale (MS) science and engineering have evolved from a range of ideas and solutions that are re ective of their original problem domains. As a result, research in MS science has followed widely diverse and disjoint paths, which present a barrier to cross pollination of ideas and application of methods outside their application(More)
In this paper we study the liveness of several MUTEX solutions by representing them as processes in PAFASs, a CCS-like process algebra with a specific operator for modelling non-blocking reading behaviours. Verification is carried out using the tool FASE, exploiting a correspondence between violations of the liveness property and a special kind of cycles(More)
In this paper, we present FASE (Faster Asynchronous Systems Evaluation), a tool for evaluating the worst-case efficiency of asynchronous systems. The tool is based on some well-established results in the setting of a timed process algebra (PAFAS: a Process Algebra for Faster Asynchronous Systems). To show the applicability of FASE to concrete meaningful(More)
The Shape Calculus is a bio-inspired timed and spatial calculus for describing 3D geometrical shapes moving in a space. Shapes, combined with a behaviour, form 3D processes, i.e., individual entities able to bind with other processes on compatible spatial channels and to split over previously established bonds. Due to geometrical space, timed behaviours, a(More)
The simulation and visualization of biological system models are becoming more and more important, in both clinical and research activities. Many tools help biologists and bioengineers to analyse and to study complex biological phenomena, such as disease spreading, tissue development and neurological reactivity. We present ongoing work onBioShape, a(More)
Nowadays, multiscale modelling is recognized as the most suitable way to study biological processes. Indeed, almost every phenomenon in nature exhibits a multiscale behaviour, i.e., it is the outcome of interactions that occur at different spatial and temporal scales. Although several ways to provide “multilayer” models have been proposed, only Complex(More)
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