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This study presents the Italian validation of the recently developed Edinburgh Cognitive and Behavioural ALS Screen (ECAS), a short screen for cognitive/behavioural alterations in patients with amyotrophic lateral sclerosis (ALS). We evaluated the psychometric properties of the ECAS Italian version in terms of reliability and convergent validity for both(More)
There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G4C2 repeat expansion in the C9ORF72 gene as the most common genetic cause of ALS has opened up new avenues for therapeutic intervention for this form of ALS. G4C2 repeat expansion RNAs and proteins of repeating dipeptides(More)
The use of augmentative and alternative communication (AAC) tools in patients with amyotrophic lateral sclerosis (ALS), as effective means to compensate for the progressive loss of verbal and gestural communication, has been deeply investigated in the recent literature. The development of advanced AAC systems, such as eye-tracking (ET) and brain-computer(More)
OBJECTIVE To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). METHODS We recruited 15 ALS patients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together(More)
Traditional cognitive assessment in neurological conditions involving physical disability is often prevented by the presence of verbal–motor impairment; to date, an extensive motor–verbal-free neuropsychological battery is not available for such purposes. We adapted a set of neuropsychological tests, assessing language, attentional abilities, executive(More)
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease. Cognitive deficits are known to be present in some ALS patients. Recently, it has been hypothesized that most ALS patients show cognitive impairments of one sort or the other. In this study we explore the capability of a combined use of Brain Computer Interface and Eye-Tracking(More)
BACKGROUND AND OBJECTIVE Counterfactual thinking (CFT) refers to the generation of mental simulations of alternatives to past events, actions and outcomes. CFT is a pervasive cognitive feature in every-day life and is closely related to decision-making, planning and problem-solving - all of which are cognitive processes linked to unimpaired frontal lobe(More)
In this study we explored the use of Brain Computer Interface (BCI) and Eye-Tracking (ET) technology both as augmentative and alternative communication (AAC) tool and to assess cognitive deficits. Specifically, we focused on the possible development of a neuropsychological battery for cognitive assessment based on the integration of BCI and ET tools. To(More)
Pathophysiological evidence suggests an involvement of frontostriatal circuits in Tourette syndrome (TS) and cognitive abnormalities have been detected in tasks sensitive to cognitive deficits associated with prefrontal damage (verbal fluency, planning, attention shifting, working memory, cognitive flexibility, and social reasoning). A disorder in(More)