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The animal trypanosomiases and their chemotherapy: a review
- Federica Giordani, L. Morrison, T. Rowan, H. D. de Koning, M. Barrett
- 10 October 2016
This review provides a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance.
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
It is shown that the most efficacious subclass of these compounds are prodrugs activated by trypanosome serine carboxypeptidases (CBPs), and CRISPR-Cas9 editing proved that partial deletion within the locus was sufficient to confer resistance.
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
- E. A. Dickie, Federica Giordani, M. Barrett
- MedicineTropical medicine and infectious disease
- 19 February 2020
The remarkable successes in combating HAT through the twenty first century are described, bringing the prospect of the elimination of this disease into sight.
Trypanocidal nitroimidazole derivatives: relationships among chemical structure and genotoxic activity.
Cytotoxic and genotoxic potential of drinking water: a comparison between two different concentration methods.
Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites
Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease
David Livingstone's life and his contributions to understanding parasitic diseases are outlined and his graphic writing allows us to explore his own encounters with tropical diseases and how European visitors to Africa considered them at this time.
Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human African Trypanosomiasis
An evaluation of a melamino nitroheterocycle, a potential lead for further development as an agent against human African trypanosomiasis (HAT), revealed that the compound induces DNA damage by a mechanism apparently independent from nitroreduction and involving the introduction of base pair substitutions.
Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity.
Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1
61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with P TR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity.