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The animal trypanosomiases and their chemotherapy: a review
TLDR
This review provides a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance.
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
TLDR
It is shown that the most efficacious subclass of these compounds are prodrugs activated by trypanosome serine carboxypeptidases (CBPs), and CRISPR-Cas9 editing proved that partial deletion within the locus was sufficient to confer resistance.
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
TLDR
The remarkable successes in combating HAT through the twenty first century are described, bringing the prospect of the elimination of this disease into sight.
Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease
TLDR
David Livingstone's life and his contributions to understanding parasitic diseases are outlined and his graphic writing allows us to explore his own encounters with tropical diseases and how European visitors to Africa considered them at this time.
Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human African Trypanosomiasis
TLDR
An evaluation of a melamino nitroheterocycle, a potential lead for further development as an agent against human African trypanosomiasis (HAT), revealed that the compound induces DNA damage by a mechanism apparently independent from nitroreduction and involving the introduction of base pair substitutions.
Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1
TLDR
61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with P TR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity.
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