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Changes in metabolic status gate reproductive activity by still incompletely deciphered mechanisms. Many neuropeptides have been shown to be involved in restraining hypothalamic gonadotropin releasing hormone (GnRH) release under conditions of negative energy balance. Broadly, on the basis of their effect on feeding, these can be grouped as orexigenic and(More)
Amplification of the neurosecretory activity of the GnRH system is the defining neuroendocrine event for sexual maturation. The physiological mechanisms that drive GnRH secretion at puberty have been difficult to identify but the discovery in 2003 that the G protein coupled receptor KISS1R is a key regulator of pubertal development in mice and men has(More)
In our previous work, we demonstrated that the intracerebroventricular (i.c.v.) injection of an interleukin-1 receptor antagonist (IL-1ra) prevented the impairment in vasopressin secretion and increased survival rate in septic rats. Additionally, we saw a reduction in nitric oxide (NO) levels in cerebroventricular spinal fluid (CSF), suggesting that the(More)
Recently, kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH), two counteracting neuropeptides, have been acknowledged as significant regulators of reproductive function. KP stimulates reproduction while GnIH inhibits it. These two neuropeptides seem to be pivotal for the modulation of reproductive activity in response to internal and external cues.(More)
Exact string matching algorithms are essential components in practical applications of the computer system. In this research we propose a new concept to solve the problem of exact string matching by scanning text string for the rightmost character of the pattern in preprocessing phase. In matching phase TSPRC (Test Scanning for Pattern Rightmost Character)(More)
Kisspeptin-Kiss1R signalling in mammals has been implicated as an integral part of the reproductive cascade. Kisspeptinergic neurons upstream of GnRH neurons are involved in the activation of the hypothalamic GnRH pulse generator during pubertal onset. Thus, the major research focus has been on the central effects of kisspeptin. The demonstration of the(More)
E-government and E-Commerce facilities help citizens to benefit from governmental services and shopping facilities while being at home. Website design is an essential part of e-government and e-commerce infrastructures. Usability aspects can enhance the user experience and lack of usability can de-motivate users and eventually they may leave that portal. In(More)
Exact String matching is an important subject in the domain of text processing and an essential component in practical applications of computer system. In this research we proposed a new algorithm to solve the problem of exact string matching by scanning text string for last and first characters of pattern in its preprocessing phase. In matching phase of(More)
Kisspeptin signaling is suppressed by short term fasting. It has been reported that hypothalamic Kiss1 and Kiss1r mRNA expression decreased after 48h of fasting in male rhesus monkey. But the mechanism involved in the reduction of kisspeptin signaling after 48h of fasting is unknown. Recent studies have suggested the role of afferent excitatory and(More)