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Thiocarboxamidocinnamonitrile derivatives2 a-f reacted with 3-aminopyrazole derivatives3 a-c to give the pyrazole[3,2-b]pyrimidine derivatives6 a-p. Compounds6 a-p were used as starting material for syntheses of several heterocylic coompounds. Dehydrogenation of6 gave pyrazole[3,2-b]pyrimidines10 a-d while its reaction with diethyl oxalate gave11. Reactions… (More)
The reaction of thiocyanoacetamide (1) with alpha,beta-unsaturated ketones 2a,b resulted in the formation of the corresponding newly synthesized 1(H)-pyridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-aryl-, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a… (More)
A novel method for the microdetermination of vitamin D2 in its pure state and pharmaceutical preparations using N-bromosuccinimide (NBS) is reported. The new method is easy, simple, and accurate.
6-Aryl-5-cyano-4-pyrimidinon-2-thione derivatives1a-c reacted with ethyl iodide to give the corresponded 2-S-ethylpyrimidin-4-one derivatives2a-c. Compounds2a-c was, in turn, reacted with hydrazine hydrate to give the sulfur free reaction products,3a-c. These reaction products were taken as the starting materials for the synthesis of several newly… (More)
This study aimed for the synthesis of new heterocyclic compounds incorporating sulfamoyl moiety suitable for use as antimicrobial agents via a versatile, readily accessible N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (3). The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with acetylacetone or arylidenes malononitrile. Cycloaddition… (More)