Fawziya Karim

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Metabotropic glutamate receptors are expressed abundantly in the spinal cord and have been shown to play important roles in the modulation of nociceptive transmission and plasticity. Most previous studies have focused on the group I metabotropic glutamate receptors (mGluR1 and mGluR5) and activation of phospholipase C signaling by these receptors in(More)
The amino acid glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate activates ionotropic glutamate receptors (iGluRs) which include the NMDA, AMPA and kainate receptors, and the metabotropic glutamate receptors (mGluRs) which are coupled to G proteins. To date, eight mGluR subtypes have been cloned and are(More)
The engineering of drug-encapsulated targeted nanoparticles (NPs) has the potential to revolutionize drug therapy. A major challenge for the smooth translation of targeted NPs to the clinic has been developing methods for the prediction and optimization of the NP surface composition, especially when targeting ligands (TL) of different chemical properties(More)
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