Fatma Z. Kutay

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abundant intracellular thiol compound present in virtually all mammalian tissues -• Functions of GSH in reductive processes are essential for the synthesis and also degradation of proteins, formation of the deoxyribonucleotid precursors of deoxyribonucleic acid (DNA), regulation of enzymes, and protection of the cells against reactive oxygen species and(More)
Abnormal glutamate metabolism is implied in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS) and cerebrospinal fluid (CSF) glutamate levels appear to be elevated. Since nitric oxide (NO) inhibits glutamate transport, excessive amounts of nitric oxide could underlie the glutamate induced neurotoxicity in ALS. Stable metabolites of NO (NO2- + NO3-)(More)
The aim of this study was to observe membrane injury and to investigate the mechanism of antioxidant defence systems against acute ethanol toxicity. Erythrocyte superoxide dismutase and Na+, K(+)-ATPase activities were significantly decreased and catalase levels were significantly increased one hour after ethanol intoxication of male swiss albino rats.(More)
Collagen, as a fibrous protein constituting approximately one third of the total protein in the body is synthesized by fibroblasts and is a major component of extracellular matrix in many tissues such as vessels, heart, kidney, liver, skin, tendons, bone and cartilage. The collagen molecule consists of three polypeptide chains which have three main amino(More)
The activities of SOD and catalase were measured in the cerebral cortex and cerebellum of Swiss male albino rats aged either 2 months (n=11) or 16 months (n=14). Tissue SOD activities were determined by Misra and Fridovich’s method while catalase activities were measued by a modified method of Luck and Aebi. When the results of this study were evaluated(More)
It has been reported that fish oil protects the rat liver against acetaminophen (APAP) induced toxicity; however, this finding is controversial. The present study was undertaken to investigate the effects of fish oil-enriched diet on APAP-induced liver injury in Wistar rats. Rats were fed a diet supplemented with either 8% fish oil or 8% corn oil, or(More)
After the recognition of nitric oxide (NO) as a messenger molecule in the nervous system, carbon monoxide (CO) has received attention with similar properties. The present study aims to elucidate the effects of CO on synaptosomal dopamine (3H-DA) and glutamate (3H-Glu) uptake and on cGMP levels; possible interaction between NO and CO systems was also(More)
Studies in animal models suggest that oxygen radicals are important in the pathogenesis of acute pancreatitis. Cerulein, a decapeptide isolated from the skin of the frog, Hyla caerula, is closely related to the C-terminus of cholecystokinin and it is a potent stimulant of pancreatic exocrine secretion. The aim of the present study was to measure the(More)
Erythrocyte membrane Na+,K+: Ca2+ ATP ase activities, cholesterol (CH) phospholipid (PL) composition and erythrocyte glutathione (GSH) contents were determined in controls, in patients with chronic active hepatitis and liver cirrhosis. NA+,K+ ATP ase activities were significantly (P < 0.0001) less in patients with chronic active hepatitis and liver(More)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by myelin breakdown. The free radical nitric oxide (NO), which is considered to be a major metabolite in immune function and in autoimmune disorders, is among the possible mediators causing the inflammatory reactions in MS. Consequently, NO has been implicated in(More)