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Membrane Active Peptides and Their Biophysical Characterization
In the last 20 years, an increasing number of studies have been reported on membrane active peptides. These peptides exert their biological activity by interacting with the cell membrane, either toExpand
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An OMIC approach to elaborate the antibacterial mechanisms of different alkaloids.
Plant-derived substances have regained interest in the fight against antibiotic resistance owing to their distinct antimicrobial mechanisms and multi-target properties. With the recent advances inExpand
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The effects of cell recycling on the production of 1,3-propanediol by Klebsiella pneumoniae
Abstract The effects of both biomass age and cell recycling on the 1,3-propanediol (1,3-PDO) production by Klebsiella pneumoniae were investigated in a membrane-supported bioreactor usingExpand
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Response of Escherichia coli to Prolonged Berberine Exposure.
Berberine is a plant-derived alkaloid possessing antimicrobial activity; unfortunately, its efflux through multidrug resistance pumps reduces its efficacy. Cellular life span of Escherichia coli isExpand
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An evolutionarily conserved allosteric site modulates beta-lactamase activity
Abstract Declining efficiency of antibiotic-inhibitor combinatorial therapies in treating beta-lactamase mediated resistance necessitates novel inhibitor development. Allosteric inhibition offers anExpand
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What Are the Multi-Omics Mechanisms for Adaptation by Microorganisms to High Alkalinity? A Transcriptomic and Proteomic Study of a Bacillus Strain with Industrial Potential.
Alkaliphilic organisms are among an industrially important class of extremophile microorganisms with the ability to thrive at pH 10-11.5. Microorganisms that exhibit alkaliphilic characteristics areExpand
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Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli
Among the different families of plant alkaloids, (-)-roemerine, an aporphine type, was recently shown to possess significant antibacterial activity in Escherichia coli. Based on the increasing demandExpand
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Targeting a hidden site on class A beta-lactamases.
Increasing resistance against available orthosteric beta-lactamase inhibitors necessitates the search for novel and powerful inhibitor molecules. In this respect, allosteric inhibitors serve asExpand
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Repurposing bioactive aporphine alkaloids as efflux pump inhibitors.
Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with efflux pumpExpand