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AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses
Significance Zika virus (ZIKV) causes microcephaly, whereas other related pathogenic flaviviruses do not. To reach the fetal brain, a virus must be transported from the maternal to the fetalExpand
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PAR1 contributes to influenza A virus pathogenicity in mice.
Influenza causes substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely to emerge in the future. Protease-activated receptor 1 (PAR1) is a thrombin-activatedExpand
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Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.
RATIONALE The hallmark of severe influenza virus infection is excessive inflammation of the lungs. Platelets are activated during influenza, but their role in influenza virus pathogenesis andExpand
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Plasminogen Controls Inflammation and Pathogenesis of Influenza Virus Infections via Fibrinolysis
Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process areExpand
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Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice
Antibody-dependent enhancement (ADE) of virus infection is common to many viruses and is problematic when plasma antibody levels decline to subneutralizing concentrations. ADE of infection isExpand
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Rôle de l'hémostase dans l'inflammation induite par les virus influenza A
La grippe est une maladie respiratoire aigue, due a une infection par des virus influenza et qui represente un probleme important de sante publique. Une meilleure comprehension des interactions entreExpand