Fatima Qaiser

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Protein kinase CK2 plays a critical role in cell growth, proliferation, and suppression of cell death. CK2 is overexpressed, especially in the nuclear compartment, in the majority of cancers, including prostate cancer (PCa). CK2-mediated activation of transcription factor nuclear factor kappa B (NF-κB) p65 is a key step in cellular proliferation, resulting(More)
c-Myc transcription factor is a protooncogene and a substrate of Casein Kinase 2 enzyme, both of these are upregulated in breast cancer. A Cross Sectional Analytical study with breast cancer paraffin embedded tissue sections (N=30) was conducted using Immunohistochemistry, cytoplasmic and nuclear expression of c-Myc and CK2 enzyme was determined and(More)
CK2 (official acronym for casein kinase 2 or II) is a potent suppressor of apoptosis in response to diverse apoptotic stimuli-thus its molecular downregulation or activity inhibition results in potent induction of cell death. CK2 downregulation is known to impact mitochondrial apoptotic circuitry but the underlying mechanism(s) remain unclear. Utilizing(More)
OBJECTIVES Genetic analysis of two consanguineous Pakistani families with localized autosomal recessive hypotrichosis was performed with the goal to establish genotype-phenotype correlation. MATERIALS AND METHODS Genomic DNA extraction had been done from peripheral blood samples. Extracted DNA was then subjected to PCR (polymerase chain reaction) for(More)
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